Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation
- Author
- KIM, Sol1 ; LEE, Jungwoon1 ; JA YOUNG KIM1 ; LIM, Bobae1 ; SHIN, Eung-Kyun1 ; HAN, Yong-Mahn2 ; KIM, Sung-Su3 ; SONG, Jin-Ho4 ; KIM, Jungho1
[1] Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul, Korea, Republic of
[2] Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of
[3] Department of Medicine, College of Medicine, Chung-Ang University, Seoul, Korea, Republic of
[4] Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Korea, Republic of - Source
International journal of cancer (Print). = Journal international du cancer. 2009, Vol 124, Num 10, pp 2312-2322, 11 p ; ref : 47 ref
- CODEN
- IJCNAW
- ISSN
- 0020-7136
- Scientific domain
- Medical oncology
- Publisher
- Wiley-Blackwell, Hoboken, NJ
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- EWS-Oct-4 bone and soft-tissue tumors chromosomal translocation dominant negative self-association transactivation transformation
- Keyword (fr)
- Activité biologique Cancérologie Caractère récessif DNA Expression génique Gène onc cellulaire Gène onc Génétique Mutation Partie molle Protooncogène Résultat négatif Site fixation Tissu tumoral Translocation chromosomique Facteur de transcription Oct4 Gène EWS Tumeur osseuse Aberration chromosomique Chromosome anormal Pathologie du système ostéoarticulaire
- Keyword (en)
- Biological activity Cancerology Recessive character DNA Gene expression C-Onc gene Onc gene Genetics Mutation Soft tissue Protooncogene Negative result Binding site Tumoral tissue Chromosome translocation Transcription factor Oct4 Bone tumor Chromosomal aberration Abnormal chromosome Diseases of the osteoarticular system
- Keyword (es)
- Actividad biológica Cancerología Carácter recesivo DNA Expresión genética Gen onc celular Gen onc Genética Mutación Parte blanda Protooncogen Resultado negativo Sitio fijación Tejido tumoral Translocación cromosómica Aberración cromosómica Cromosoma anormal Sistema osteoarticular patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations
- Discipline
- Medical genetics Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21303800
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/ijc.24228 
https://dx.doi.org/10.1002/ijc.24228
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