Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients
- Author
- BULITTA, Jiirgen B1 ; PING ZHAO2 ; JUSKO, William J1 ; ARNOLD, Robert D1 ; KESSLER, Dean R2 ; DAIFUKU, Richard2 ; PRATT, James2 ; LUCIANO, Gabriel2 ; HANAUSKE, Axel-R3 ; GELDERBLOM, Hans4 ; AWADA, Ahmad5
[1] Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Hochstetter Hall, Room 565, Buffalo, NY 14260-1200, United States
[2] Sonus Pharmaceuticals, Inc, Bothell, WA 98021, United States
[3] Department of Medical Oncology, St. Georg Hospital, Lohmühlenstr. 5, 20099 Hamburg, Germany
[4] Department of Clinical Oncology, Leiden University Medical Center, Leiden, Netherlands
[5] Institut Jules Bordet, Rue Heger-Bordet 1, 1000 Brussels, Belgium - Source
Cancer chemotherapy and pharmacology. 2009, Vol 63, Num 6, pp 1035-1048, 14 p ; ref : 51 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- LC-MS/MS Monte Carlo simulation; Neutrophils/toxicity Multiple-pool cell lifespan model Non-hematological malignancies Paclitaxel Population pharmacokinetics and pharmacodynamics
- Keyword (fr)
- Activité biologique Anticancéreux Cellule Chromatographie HPLC Durée vie Formulation Granulocyte Homme Hémopathie maligne In vitro Malade Modèle Neutrophile Neutropénie Paclitaxel Pharmacocinétique de la population Relation pharmacocinétique pharmacodynamie Simulation Spectrométrie masse tandem Toxicité Tumeur maligne Pharmacodynamie Antimitotique Cancer Dérivé du taxane Leucopénie
- Keyword (en)
- Biological activity Antineoplastic agent Cell HPLC chromatography Lifetime Formulation Granulocyte Human Malignant hemopathy In vitro Patient Models Neutrophil Neutropenia Paclitaxel Population pharmacokinetics Pharmacokinetic pharmacodynamic relationship Simulation Mass spectrometry MS/MS Toxicity Malignant tumor Pharmacodynamics Antimitotic Cancer Taxane derivatives Leukopenia
- Keyword (es)
- Actividad biológica Anticanceroso Célula Cromatografía HPLC Tiempo vida Formulación Granulocito Hombre Hemopatía maligna In vitro Enfermo Modelo Neutrófilo Neutropenia Paclitaxel Farmacocinética población Relación farmacocinética farmacodinamia Simulación Espectrometría masa en tándem Toxicidad Tumor maligno Farmacodinámica Antimitótico Cáncer Taxane derivado Leucopenia
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19D Other diseases. Hematologic involvement in other diseases
- Discipline
- Blood diseases Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21316278
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-008-0828-1 
https://dx.doi.org/10.1007/s00280-008-0828-1
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