Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

Author

NORTHCOTT, Paul A^{1 2 3} ; NAKAHARA, Yukiko^{1 2} ; RA, Young-Shin¹ ; ZILBERBERG, Karen^{1 2 3} ; MCLEOD, Jessica^{1 2} ; SCHERER, Stephen W^{4 5} ; SUNIL RAO, J⁸ ; EBERHART, Charles G⁹ ; GRAJKOWSKA, Wiesia¹⁰ ; GILLESPIE, Yancey¹¹ ; LACH, Boleslaw¹² ; GRUNDY, Richard¹³ ; XIAOCHONG WU^{1 2} ; POLLACK, Ian F¹⁴ ; HAMILTON, Ronald L¹⁵ ; VAN METER, Timothy¹⁶ ; CARLOTTI, Carlos G¹⁷ ; BOOP, Frederick¹⁸ ; BIGNER, Darrell¹⁹ ; GILBERTSON, Richard J^{20 21} ; RUTKA, James T^{1 3} ; TAYLOR, Michael D^{1 2 3} ; FEUK, Lars^{4 5} ; ELLISON, David W⁶ ; CROUL, Sid⁷ ; MACK, Stephen^{1 2 3} ; KONGKHAM, Paul N^{1 3} ; PEACOCK, John^{1 2} ; DUBUC, Adrian^{1 2 3}
[1] Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
[2] Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
[3] Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
[4] The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
[5] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
[6] Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee, United States
[7] Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
[8] Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States
[9] Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States
[10] Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland
[11] Department of Surgery, University of Alabama, Birmingham, Alabama, United States
[12] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
[13] University of Nottingham, Nottingham, United Kingdom
[14] Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
[15] Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
[16] Department of Neurosurgery, Medical College of Virginia, Richmond, Virginia, United States
[17] Division of Neurosurgery, Department of Surgery, Ribeirao Preto Medical School, University of São Paulo, Sao Paulo, Brazil
[18] Division of Pediatric Neurosurgery, St. Jude Children's Research Hospital, Memphis, Tennessee, United States
[19] Department of Pathology, Duke University, Durham, North Carolina, United States
[20] Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, United States
[21] Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, United States

Source

Nature genetics. 2009, Vol 41, Num 4, pp 465-472, 8 p ; ref : 30 ref

CODEN

NGENEC

ISSN

1061-4036

Scientific domain

Genetics

Publisher

Nature Publishing Group, New York, NY

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Génétique Histone Lysine Médulloblastome Méthylation Récidivant Régulation Cancer Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Tumeur maligne

Keyword (en)

Genetics Histone Lysine Medulloblastoma Methylation Recurrent Regulation(control) Cancer Cerebral disorder Central nervous system disease Nervous system diseases Malignant tumor

Keyword (es)

Genética Histona Lisina Meduloblastoma Metilación Recidivante Regulación Cáncer Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses

Discipline

Eukaryotes genetics. Biological and molecular evolution Neurology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

21344272

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS