Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain
- Author
- GURWITZ, David1 ; RODRIGUEZ-ANTONA, Cristina2 ; PAYNE, Katherine3 ; NEWMAN, William4 ; GISBERT, Javier P5 ; GUTIERREZ DE MESA, Emma6 ; IBARRETA, Dolores6
[1] Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
[2] Human Cancer Genetics Programme, Spanish National Cancer Center (CNIO), Madrid, Spain
[3] Health Methodology Research Group, University of Manchester, Manchester, United Kingdom
[4] Department of Medical Genetics, University of Manchester, Manchester, United Kingdom
[5] Gastroenterology Unit, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enferrnedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain
[6] European Commission, Joint Research Center, Institute for Prospective Technological Studies, Seville, Spain - Source
European journal of human genetics. 2009, Vol 17, Num 8, pp 991-998, 8 p ; ref : 41 ref
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- azathioprine genetic testing mercaptopurines neutropenia pharmacogenetics thiopurine S-methyltransferase
- Keyword (fr)
- Anticancéreux Azathioprine Conseil génétique Génotype Génétique Immunodépresseur Mercaptopurine Neutropénie Pharmacogénétique Pharmacovigilance Phénotype Thiopurine S-methyltransferase Espagne Europe Royaume-Uni Antimétabolite Dérivé de la purine Enzyme Hémopathie Leucopénie Methyltransferases Thiopurine dérivé Transferases
- Keyword (en)
- Antineoplastic agent Azathioprine Genetic counseling Genotype Genetics Immunosuppressive agent Mercaptopurine Neutropenia Pharmacogenetics Pharmacovigilance Phenotype Thiopurine S-methyltransferase Spain Europe United Kingdom Antimetabolic Purine derivatives Enzyme Hemopathy Leukopenia Methyltransferases Thiopurine derivatives Transferases
- Keyword (es)
- Anticanceroso Azatioprina Consejo genético Genotipo Genética Inmunodepresor Mercaptopurina Neutropenia Farmacogenética Farmacovigilancia Fenotipo Thiopurine S-methyltransferase España Europa Reino Unido Antimetabólito Purina derivado Enzima Hemopatía Leucopenia Methyltransferases Derivado de la tiopurina Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19D Other diseases. Hematologic involvement in other diseases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23A General aspects. Genetic counseling
- Discipline
- Blood diseases Eukaryotes genetics. Biological and molecular evolution Medical genetics Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21693483
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1038/ejhg.2009.10 
https://dx.doi.org/10.1038/ejhg.2009.10
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:9:\"\u0000*\u0000jtitle\";s:34:\"European journal of human genetics\";s:9:\"\u0000*\u0000stitle\";s:18:\"Eur. j. hum. genet\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:3:\"991\";s:8:\"\u0000*\u0000epage\";s:3:\"998\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1018-4813\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"GURWITZ\";s:10:\"\u0000*\u0000aufirst\";s:5:\"David\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:6:{i:0;s:26:\"RODRIGUEZ-ANTONA, Cristina\";i:1;s:16:\"PAYNE, Katherine\";i:2;s:15:\"NEWMAN, William\";i:3;s:17:\"GISBERT, Javier P\";i:4;s:23:\"GUTIERREZ DE MESA, Emma\";i:5;s:17:\"IBARRETA, Dolores\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:9:\"\u0000*\u0000jtitle\";s:34:\"European journal of human genetics\";s:9:\"\u0000*\u0000stitle\";s:18:\"Eur. j. hum. genet\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:3:\"991\";s:8:\"\u0000*\u0000epage\";s:3:\"998\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1018-4813\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"GURWITZ\";s:10:\"\u0000*\u0000aufirst\";s:5:\"David\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:6:{i:0;s:26:\"RODRIGUEZ-ANTONA, Cristina\";i:1;s:16:\"PAYNE, Katherine\";i:2;s:15:\"NEWMAN, William\";i:3;s:17:\"GISBERT, Javier P\";i:4;s:23:\"GUTIERREZ DE MESA, Emma\";i:5;s:17:\"IBARRETA, Dolores\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:9:\"\u0000*\u0000jtitle\";s:34:\"European journal of human genetics\";s:9:\"\u0000*\u0000stitle\";s:18:\"Eur. j. hum. genet\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:3:\"991\";s:8:\"\u0000*\u0000epage\";s:3:\"998\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1018-4813\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"GURWITZ\";s:10:\"\u0000*\u0000aufirst\";s:5:\"David\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:6:{i:0;s:26:\"RODRIGUEZ-ANTONA, Cristina\";i:1;s:16:\"PAYNE, Katherine\";i:2;s:15:\"NEWMAN, William\";i:3;s:17:\"GISBERT, Javier P\";i:4;s:23:\"GUTIERREZ DE MESA, Emma\";i:5;s:17:\"IBARRETA, Dolores\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:9:\"\u0000*\u0000jtitle\";s:34:\"European journal of human genetics\";s:9:\"\u0000*\u0000stitle\";s:18:\"Eur. j. hum. genet\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:3:\"991\";s:8:\"\u0000*\u0000epage\";s:3:\"998\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1018-4813\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"GURWITZ\";s:10:\"\u0000*\u0000aufirst\";s:5:\"David\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:6:{i:0;s:26:\"RODRIGUEZ-ANTONA, Cristina\";i:1;s:16:\"PAYNE, Katherine\";i:2;s:15:\"NEWMAN, William\";i:3;s:17:\"GISBERT, Javier P\";i:4;s:23:\"GUTIERREZ DE MESA, Emma\";i:5;s:17:\"IBARRETA, Dolores\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:20:\"10.1038\/ejhg.2009.10\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:9:\"\u0000*\u0000jtitle\";s:34:\"European journal of human genetics\";s:9:\"\u0000*\u0000stitle\";s:18:\"Eur. j. hum. genet\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"8\";s:8:\"\u0000*\u0000spage\";s:3:\"991\";s:8:\"\u0000*\u0000epage\";s:3:\"998\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1018-4813\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"GURWITZ\";s:10:\"\u0000*\u0000aufirst\";s:5:\"David\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:6:{i:0;s:26:\"RODRIGUEZ-ANTONA, Cristina\";i:1;s:16:\"PAYNE, Katherine\";i:2;s:15:\"NEWMAN, William\";i:3;s:17:\"GISBERT, Javier P\";i:4;s:23:\"GUTIERREZ DE MESA, Emma\";i:5;s:17:\"IBARRETA, Dolores\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:90:\"Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"8\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
