Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
- Author
- LAUCHLE, Jennifer O1 ; KIM, Doris1 ; DIAZ-FLORES, Ernesto1 ; GORMAN, Matthew1 ; PRZYBRANOWSKI, Sally6 ; TRAN, Mary1 ; KOGAN, Scott C4 ; ROOSE, Jeroen P3 ; COPELAND, Neal G7 ; JENKINS, Nancy A7 ; PARADA, Luis8 ; WOLFF, Linda9 ; LE, Doan T1 ; SEBOLT-LEOPOLD, Judith6 ; SHANNON, Kevin1 ; AKAGI, Keiko5 ; CRONE, Michael1 ; KRISMAN, Kimberly1 ; WARNER, Kegan1 ; BONIFAS, Jeannette M1 ; QING LI2 ; COAKLEY, Kristen M3
[1] Department of Pediatrics, University of California, San Francisco, California 94143, United States
[2] Department of Medicine, University of California, San Francisco, California 94143, United States
[3] Department of Anatomy, University of California, San Francisco, California 94143, United States
[4] Department of Laboratory Medicine, University of California, San Francisco, California 94143, United States
[5] Mouse Cancer Genetics Program, National Cancer Institute, Fredrick, Maryland 21702, United States
[6] Pfizer Global Research and Development, Ann Arbor, Michigan 48105, United States
[7] Institute of Molecular and Cell Biology, Singapore 138673, Singapore
[8] University of Texas Southwestern, Dallas, Texas 75235, United States
[9] Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States - Source
Nature (London). 2009, Vol 461, Num 7262, pp 411-414, 4 p ; ref : 25 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Animal Anticancéreux Chimiothérapie Gène onc cellulaire Gène ras In vitro In vivo Inhibiteur enzyme Leucémie aiguë myéloblastique Protooncogène Résistance traitement Souris CI-1040 Mitogen-activated protein kinase kinase 1 Cancer Génétique Hémopathie maligne Mammalia Rodentia Traitement Vertebrata
- Keyword (en)
- Biological activity Animal Antineoplastic agent Chemotherapy C-Onc gene Ras gene In vitro In vivo Enzyme inhibitor Acute myelogenous leukemia Protooncogene Treatment resistance Mouse Mitogen-activated protein kinase kinase 1 Cancer Genetics Malignant hemopathy Mammalia Rodentia Treatment Vertebrata
- Keyword (es)
- Actividad biológica Animal Anticanceroso Quimioterapia Gen onc celular Gen ras In vitro In vivo Inhibidor enzima Leucemia aguda mieloblástica Protooncogen Resistencia tratamiento Ratón Mitogen-activated protein kinase kinase 1 Cáncer Genética Hemopatía maligna Mammalia Rodentia Tratamiento Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21901348
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature08279 
https://dx.doi.org/10.1038/nature08279
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