Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles
- Author
- ISHIHARA, Tsutomu1 2 ; TAKEDA, Miho1 ; MAEDA, Taishi1 ; YAMAKAWA, Naoki1 ; OKAMOTO, Yoshinari1 ; OTSUKA, Masami1 ; ISHIDA, Tatsuhiro1 ; KIWADA, Hiroshi4 ; MIZUSHIMA, Yutaka2 ; MIZUSHIMA, Tohru1 ; SAKAMOTO, Haruka1 ; KIMOTO, Ayumi1 ; KOBAYASHI, Chisa1 ; TAKASAKI, Naoko1 ; YUKI, Kanae1 ; TANAKA, Ken-Ichiro1 ; TAKENAGA, Mitsuko3 ; IGARASHI, Rie3
[1] Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
[2] DDS Institute, The Jikei University School of Medicine, Tokyo 105-8461, Japan
[3] Division of Drug Delivery System, Institute of Medical Science, St. Marianna University, Kawasaki 216-8512, Japan
[4] Institute of Health Bioscience, The University of Tokushima, Tokushima 770-8505, Japan - Source
Pharmaceutical research. 2009, Vol 26, Num 10, pp 2270-2279, 10 p ; ref : 41 ref
- CODEN
- PHREEB
- ISSN
- 0724-8741
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- ABC phenomenon anti-PEG IgM antibody biodegradable nanoparticles encapsulation prostaglandin E1
- Keyword (fr)
- Anticorps Biodégradabilité Clairance Encapsulation Ethylène oxyde polymère Lactique acide polymère Liquide biologique Nanoparticule Prostaglandine E1 Sang Technologie pharmaceutique Microparticule Pharmacocinétique
- Keyword (en)
- Antibody Biodegradability Clearance Encapsulation Ethylene oxide polymer Lactic acid polymer Biological fluid Nanoparticle Prostaglandin E1 Blood Pharmaceutical technology Microparticle Pharmacokinetics
- Keyword (es)
- Anticuerpo Biodegradabilidad Depuración Encapsulación Etileno óxido polímero Láctico ácido polímero Líquido biológico Nanopartícula Prostaglandina E1 Sangre Tecnología farmacéutica Micropartícula Farmacocinética
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22036851
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1007/s11095-009-9943-x 
https://dx.doi.org/10.1007/s11095-009-9943-x
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:9:\"\u0000*\u0000jtitle\";s:23:\"Pharmaceutical research\";s:9:\"\u0000*\u0000stitle\";s:10:\"Pharm. res\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"26\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"2270\";s:8:\"\u0000*\u0000epage\";s:4:\"2279\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0724-8741\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"ISHIHARA\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Tsutomu\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:12:\"TAKEDA, Miho\";i:1;s:13:\"MAEDA, Taishi\";i:2;s:15:\"YAMAKAWA, Naoki\";i:3;s:18:\"OKAMOTO, Yoshinari\";i:4;s:14:\"OTSUKA, Masami\";i:5;s:17:\"ISHIDA, Tatsuhiro\";i:6;s:15:\"KIWADA, Hiroshi\";i:7;s:17:\"MIZUSHIMA, Yutaka\";i:8;s:16:\"MIZUSHIMA, Tohru\";i:9;s:16:\"SAKAMOTO, Haruka\";i:10;s:13:\"KIMOTO, Ayumi\";i:11;s:16:\"KOBAYASHI, Chisa\";i:12;s:15:\"TAKASAKI, Naoko\";i:13;s:11:\"YUKI, Kanae\";i:14;s:18:\"TANAKA, Ken-Ichiro\";i:15;s:17:\"TAKENAGA, Mitsuko\";i:16;s:13:\"IGARASHI, Rie\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"PHREEB\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:8:\"\u0000*\u0000place\";s:12:\"New York, NY\";s:6:\"\u0000*\u0000pub\";s:8:\"Springer\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"10\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:9:\"\u0000*\u0000jtitle\";s:23:\"Pharmaceutical research\";s:9:\"\u0000*\u0000stitle\";s:10:\"Pharm. res\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"26\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"2270\";s:8:\"\u0000*\u0000epage\";s:4:\"2279\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0724-8741\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"ISHIHARA\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Tsutomu\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:12:\"TAKEDA, Miho\";i:1;s:13:\"MAEDA, Taishi\";i:2;s:15:\"YAMAKAWA, Naoki\";i:3;s:18:\"OKAMOTO, Yoshinari\";i:4;s:14:\"OTSUKA, Masami\";i:5;s:17:\"ISHIDA, Tatsuhiro\";i:6;s:15:\"KIWADA, Hiroshi\";i:7;s:17:\"MIZUSHIMA, Yutaka\";i:8;s:16:\"MIZUSHIMA, Tohru\";i:9;s:16:\"SAKAMOTO, Haruka\";i:10;s:13:\"KIMOTO, Ayumi\";i:11;s:16:\"KOBAYASHI, Chisa\";i:12;s:15:\"TAKASAKI, Naoko\";i:13;s:11:\"YUKI, Kanae\";i:14;s:18:\"TANAKA, Ken-Ichiro\";i:15;s:17:\"TAKENAGA, Mitsuko\";i:16;s:13:\"IGARASHI, Rie\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"PHREEB\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:8:\"\u0000*\u0000place\";s:12:\"New York, NY\";s:6:\"\u0000*\u0000pub\";s:8:\"Springer\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"10\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:9:\"\u0000*\u0000jtitle\";s:23:\"Pharmaceutical research\";s:9:\"\u0000*\u0000stitle\";s:10:\"Pharm. res\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"26\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"2270\";s:8:\"\u0000*\u0000epage\";s:4:\"2279\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0724-8741\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"ISHIHARA\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Tsutomu\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:12:\"TAKEDA, Miho\";i:1;s:13:\"MAEDA, Taishi\";i:2;s:15:\"YAMAKAWA, Naoki\";i:3;s:18:\"OKAMOTO, Yoshinari\";i:4;s:14:\"OTSUKA, Masami\";i:5;s:17:\"ISHIDA, Tatsuhiro\";i:6;s:15:\"KIWADA, Hiroshi\";i:7;s:17:\"MIZUSHIMA, Yutaka\";i:8;s:16:\"MIZUSHIMA, Tohru\";i:9;s:16:\"SAKAMOTO, Haruka\";i:10;s:13:\"KIMOTO, Ayumi\";i:11;s:16:\"KOBAYASHI, Chisa\";i:12;s:15:\"TAKASAKI, Naoko\";i:13;s:11:\"YUKI, Kanae\";i:14;s:18:\"TANAKA, Ken-Ichiro\";i:15;s:17:\"TAKENAGA, Mitsuko\";i:16;s:13:\"IGARASHI, Rie\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"PHREEB\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:8:\"\u0000*\u0000place\";s:12:\"New York, NY\";s:6:\"\u0000*\u0000pub\";s:8:\"Springer\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"10\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:9:\"\u0000*\u0000jtitle\";s:23:\"Pharmaceutical research\";s:9:\"\u0000*\u0000stitle\";s:10:\"Pharm. res\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"26\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"2270\";s:8:\"\u0000*\u0000epage\";s:4:\"2279\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0724-8741\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"ISHIHARA\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Tsutomu\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:12:\"TAKEDA, Miho\";i:1;s:13:\"MAEDA, Taishi\";i:2;s:15:\"YAMAKAWA, Naoki\";i:3;s:18:\"OKAMOTO, Yoshinari\";i:4;s:14:\"OTSUKA, Masami\";i:5;s:17:\"ISHIDA, Tatsuhiro\";i:6;s:15:\"KIWADA, Hiroshi\";i:7;s:17:\"MIZUSHIMA, Yutaka\";i:8;s:16:\"MIZUSHIMA, Tohru\";i:9;s:16:\"SAKAMOTO, Haruka\";i:10;s:13:\"KIMOTO, Ayumi\";i:11;s:16:\"KOBAYASHI, Chisa\";i:12;s:15:\"TAKASAKI, Naoko\";i:13;s:11:\"YUKI, Kanae\";i:14;s:18:\"TANAKA, Ken-Ichiro\";i:15;s:17:\"TAKENAGA, Mitsuko\";i:16;s:13:\"IGARASHI, Rie\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"PHREEB\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:8:\"\u0000*\u0000place\";s:12:\"New York, NY\";s:6:\"\u0000*\u0000pub\";s:8:\"Springer\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"10\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:25:\"10.1007\/s11095-009-9943-x\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:9:\"\u0000*\u0000jtitle\";s:23:\"Pharmaceutical research\";s:9:\"\u0000*\u0000stitle\";s:10:\"Pharm. res\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"26\";s:8:\"\u0000*\u0000issue\";s:2:\"10\";s:8:\"\u0000*\u0000spage\";s:4:\"2270\";s:8:\"\u0000*\u0000epage\";s:4:\"2279\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0724-8741\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"ISHIHARA\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Tsutomu\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:12:\"TAKEDA, Miho\";i:1;s:13:\"MAEDA, Taishi\";i:2;s:15:\"YAMAKAWA, Naoki\";i:3;s:18:\"OKAMOTO, Yoshinari\";i:4;s:14:\"OTSUKA, Masami\";i:5;s:17:\"ISHIDA, Tatsuhiro\";i:6;s:15:\"KIWADA, Hiroshi\";i:7;s:17:\"MIZUSHIMA, Yutaka\";i:8;s:16:\"MIZUSHIMA, Tohru\";i:9;s:16:\"SAKAMOTO, Haruka\";i:10;s:13:\"KIMOTO, Ayumi\";i:11;s:16:\"KOBAYASHI, Chisa\";i:12;s:15:\"TAKASAKI, Naoko\";i:13;s:11:\"YUKI, Kanae\";i:14;s:18:\"TANAKA, Ken-Ichiro\";i:15;s:17:\"TAKENAGA, Mitsuko\";i:16;s:13:\"IGARASHI, Rie\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"PHREEB\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:96:\"Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles\";s:8:\"\u0000*\u0000place\";s:12:\"New York, NY\";s:6:\"\u0000*\u0000pub\";s:8:\"Springer\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"10\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
