Inhibition of cytochrome P450-dependent monooxygenases by an alkaloid fraction from Helietta apiculata markedly potentiate the hypnotic action of pentobarbital
- Author
- GOLOUBKOVA, T. D1 ; HECKLER, E2 ; RATES, S. M. K2 ; HENRIQUES, J. A. P1 ; HENRIQUES, A. T2
[1] Center of Biotechnology, UFRGS, Porto Alegre, 91501-970 RS, Brazil
[2] Graduate Course in Pharmaceutical Sciences, School of Pharmacy, UFRGS, Av. Ipiranga 2752, Porto Alegre, 90610-000 RS, Brazil - Source
Journal of ethnopharmacology. 1998, Vol 60, Num 2, pp 141-148 ; ref : 20 ref
- CODEN
- JOETD7
- ISSN
- 0378-8741
- Scientific domain
- Social anthropology and ethnology; Pharmacology drugs
- Publisher
- Elsevier, Shannon
- Publication country
- Ireland
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Alcaloïde Analyse structurale Animal Association médicamenteuse Barbituriques Cytochrome P450 Feuille végétal Hypnotique Inhibiteur enzyme Médecine traditionnelle Origine végétale Pentobarbital Pharmacognosie Plante médicinale Quinoléine dérivé Rat Souris Sédatif Toxicité Unspecific monooxygenase Voie intrapéritonéale Furoquinoléine dérivé Helietta apiculata Paraguay Angiospermae Dicotyledones Enzyme Mammalia Oxidoreductases Rodentia Rutaceae Spermatophyta Vertebrata Amérique du Sud Amérique
- Keyword (en)
- Biological activity Alkaloid Structural analysis Animal Drug combination Barbiturates Cytochrome P450 Plant leaf Hypnotic Enzyme inhibitor Folk medicine Plant origin Pentobarbital Pharmacognosy Medicinal plant Quinoline derivatives Rat Mouse Sedative Toxicity Unspecific monooxygenase Intraperitoneal administration Paraguay Angiospermae Dicotyledones Enzyme Mammalia Oxidoreductases Rodentia Rutaceae Spermatophyta Vertebrata South America America
- Keyword (es)
- Actividad biológica Alcaloide Análisis estructural Animal Asociación medicamentosa Barbitúricos Citocromo P450 Hoja vegetal Hipnótico Inhibidor enzima Medicina tradicional Origen vegetal Pentobarbital Farmacognosia Planta medicinal Quinolina derivado Rata Ratón Sedante Toxicidad Unspecific monooxygenase Vía intraperitoneal Paraguay Angiospermae Dicotyledones Enzima Mammalia Oxidoreductases Rodentia Rutaceae Spermatophyta Vertebrata America del sur America
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2206598
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0378-8741(97)00139-6 
https://dx.doi.org/10.1016/S0378-8741(97)00139-6
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