Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- Author
- YAUCH, Robert L1 ; DIJKGRAAF, Gerrit J. P1 ; BAZAN, J. Fernando1 ; ZHENGYAN KAN1 ; SESHAGIRI, Somasekar1 ; HANN, Christine L2 ; GOULD, Stephen E1 ; LOW, Jennifer A1 ; RUDIN, Charles M2 ; DE SAUVAGE, Frederic J1 ; ALICKE, Bruno1 ; JANUARIO, Thomas1 ; AHN, Christina P1 ; HOLCOMB, Thomas1 ; PUJARA, Kanan1 ; STINSON, Jeremy1 ; CALLAHAN, Christopher A1 ; TANG, Tracy1
[1] Genentech, South San Francisco, CA 94080, United States
[2] Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, United States - Source
Science (Washington, D.C.). 2009, Vol 326, Num 5952, pp 572-574, 3 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide aspartique Animal Ciblage Evolution Homme Modèle Mutation Mécanisme Médulloblastome Pathogénie Pronostic Protéine G Résistance traitement Souris Symptomatologie Tumeur intracrânienne Tumeur maligne Cancer Mammalia Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Rodentia Vertebrata
- Keyword (en)
- Aspartic acid Animal Targeting Evolution Human Models Mutation Mechanism Medulloblastoma Pathogenesis Prognosis G protein Treatment resistance Mouse Symptomatology Intracranial tumor Malignant tumor Cancer Mammalia Cerebral disorder Central nervous system disease Nervous system diseases Rodentia Vertebrata
- Keyword (es)
- Acido aspártico Animal Blancado Evolución Hombre Modelo Mutación Mecanismo Meduloblastoma Patogenia Pronóstico Proteína G Resistencia tratamiento Ratón Sintomatología Tumor intracraneal Tumor maligno Cáncer Mammalia Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22076402
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1179386 
https://dx.doi.org/10.1126/science.1179386
