Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
- Author
- HASEGAWA, H1 ; YAMADA, Y1 ; IHA, H2 ; TSUKASAKI, K3 ; NAGAI, K4 ; ATOGAMI, S1 ; SUGAHARA, K1 ; TSURUDA, K1 ; LSHIZAKI, A1 ; KAMIHIRA, S1
[1] Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
[2] Department of Infectious Diseases, Faculty of Medicine, Oita University, Yufu, Oita, Japan
[3] Department of Hematology, Atomic Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
[4] Transfusion Service, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan - Source
Leukemia. 2009, Vol 23, Num 11, pp 2090-2101, 12 p ; ref : 58 ref
- CODEN
- LEUKED
- ISSN
- 0887-6924
- Scientific domain
- Medical oncology; Hematology
- Publisher
- Nature Publishing Group, Avenel, NJ
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Nutlin adult T-cell leukemia apoptosis p14ARF p53 senescence
- Keyword (fr)
- Antagoniste Apoptose Gène TP53 Gène mdm2 Gène onc cellulaire Gène suppresseur tumeur Hématologie Leucémie de l'adulte à cellules T Mort cellulaire Protooncogène Sénescence Virus HTLV1 Gène p14ARF Gène p53 Nutline Cancer Deltaretrovirus Hémopathie maligne Infection Retroviridae Syndrome lymphoprolifératif Virose Virus
- Keyword (en)
- Antagonist Apoptosis TP53 Gene mdm2 Gene C-Onc gene Tumor suppressor gene Hematology Adult T cell leukemia Cell death Protooncogene Senescence HTLV-I virus Nutlin Cancer Deltaretrovirus Malignant hemopathy Infection Retroviridae Lymphoproliferative syndrome Viral disease Virus
- Keyword (es)
- Antagonista Apoptosis Gen TP53 Gen mdm2 Gen onc celular Gen supresor tumor Hematología Leucemia célula T adulta Muerte celular Protooncogen Senescencia HTLV-I virus Cáncer Deltaretrovirus Hemopatía maligna Infección Retroviridae Linfoproliferativo síndrome Virosis Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Infectious pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22149418
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/leu.2009.171 
https://dx.doi.org/10.1038/leu.2009.171
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