Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Author

BARBIE, David A^{1 3 4} ; TAMAYO, Pablo³ ; FRÖHLING, Stefan⁶ ; CHAN, Edmond M³ ; SOS, Martin L⁹ ; MICHEL, Kathrin⁹ ; MERMEL, Craig^{1 3} ; SILVER, Serena J³ ; WEIR, Barbara A³ ; REILING, Jan H^{10 7} ; QING SHENG¹ ; GUPTA, Piyush B³ ; BOEHM, Jesse S³ ; WADLOW, Raymond C⁴ ; HANH LE; HOERSCH, Sebastian⁸ ; WITTNER, Ben S⁴ ; RAMASWAMY, Sridhar⁴ ; LIVINGSTON, David M¹ ; SABATINI, David M^{10 7} ; MEYERSON, Matthew^{1 2} ; THOMAS, Roman K^{11 12 9} ; LANDER, Eric S⁷ ; SO YOUNG KIM^{1 2} ; MESIROV, Jill P; ROOT, David E; GILLILAND, D. Gary¹ ; JACKS, Tyer^{7 8} ; HAHN, William C^{1 2 6} ; MOODY, Susan E^{1 3} ; DUNN, Ian F^{1 3 5} ; SCHINZEL, Anna C^{1 3} ; SANDY, Peter^{7 8} ; MEYLAN, Etienne^{7 8} ; SCHOLL, Claudia⁶
[1] Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United States
[2] Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United States
[3] Broad Institute of Harvard and M.LT., 7 Cambridge Center, Cambridge, Massachusetts 02142, United States
[4] Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, Massachusetts 02114, United States
[5] Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
[6] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
[7] Department of Biology, M,LT., 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
[8] Koch Institute for Integrative Cancer Research, 40 Ames Street, Cambridge, Massachusetts 02142, United States
[9] Max Planck Institute for Neurological Research with Klaus-Joachlm-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, Gleueler Str. 50, 50931 Köln, Germany
[10] Whitehead Institute of Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States
[11] Department I of Internal Medicine and Center of Integrated Oncology, University of Köln, Gleueler Str. 50, 50931 Köln, Germany
[12] Chemical Genomics Center of the Max-Planck-Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany

Source

Nature (London). 2009, Vol 462, Num 7269, pp 108-112, 5 p ; ref : 28 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Cancérologie Carcinogenèse Gène K ras Gène onc cellulaire Homme Interférence ARN Non-specific serine/threonine protein kinase Protooncogène Tumeur maligne Serine/threonine-protein kinase TBK1 Cancer Enzyme Génétique Silence expression génique Transferases

Keyword (en)

Cancerology Carcinogenesis K ras Gene C-Onc gene Human RNA interference Non-specific serine/threonine protein kinase Protooncogene Malignant tumor Cancer Enzyme Genetics Gene silencing Transferases

Keyword (es)

Cancerología Carcinogénesis Gen K ras Gen onc celular Hombre ARN interferencia Non-specific serine/threonine protein kinase Protooncogen Tumor maligno Cáncer Enzima Genética Silencio expresión genética Transferases

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04E Carcinogenesis, carcinogens and anticarcinogens / 002B04E01 General aspects

Discipline

Tumours

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

22184618

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS