Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- Author
- DANG, Lenny1 ; WHITE, David W1 ; MARKS, Kevin M1 ; PRINS, Robert M3 ; WARD, Patrick S4 ; YEN, Katharine E1 ; LIAU, Linda M3 ; RABINOWITZ, Joshua D2 ; CANTLEY, Lewis C5 ; THOMPSON, Craig B4 ; VANDER HEIDEN, Matthew G1 ; SU, Shinsan M1 ; GROSS, Stefan1 ; BENNETT, Bryson D2 ; BITTINGER, Mark A1 ; DRIGGERS, Edward M1 ; FANTIN, Valeria R1 ; HYUN GYUNG JANG1 ; SHENGFANG JIN1 ; KEENAN, Marie C1
[1] Agios Pharmaceuticals, Cambridge, Massachusetts 02139, United States
[2] Department of Chemistry and Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States
[3] Department of Neurosurgery, UCLA Medical School, Los Angeles, California 90095, United States
[4] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
[5] Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States - Source
Nature (London). 2009, Vol 462, Num 7274, pp 739-744, 6 p ; ref : 19 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancérologie Carcinogenèse Gliome malin Gène Homme Isocitrate dehydrogenase (NADP+) Mutation Métabolite Progression carcinogenèse Glutarate(2-hydroxy) Cancer Enzyme Génétique Oxidoreductases Pathologie du système nerveux central Pathologie du système nerveux Tumeur maligne
- Keyword (en)
- Cancerology Carcinogenesis Malignant glioma Gene Human Isocitrate dehydrogenase (NADP+) Mutation Metabolite Tumor progression Cancer Enzyme Genetics Oxidoreductases Central nervous system disease Nervous system diseases Malignant tumor
- Keyword (es)
- Cancerología Carcinogénesis Glioma maligno Gen Hombre Isocitrate dehydrogenase (NADP+) Mutación Metabolito Progresión carcinogénesis Cáncer Enzima Genética Oxidoreductases Sistema nervosio central patología Sistema nervioso patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22189628
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature08617 
https://dx.doi.org/10.1038/nature08617
