Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
- Author
- ROSENGREN, Anders H1 ; JOKUBKA, Ramunas1 ; GROOP, Leif1 ; RORSMAN, Patrik4 ; SALEHI, Albert1 ; LYSSENKO, Valeriya1 ; LUTHMAN, Holger1 ; RENSTRÖM, Erik1 ; TOJJAR, Damon1 ; GRANHALL, Charlotte1 ; HANSSON, Ola1 ; LI, Dai-Qing2 ; NAGARAJ, Vini1 ; REINBOTHE, Thomas M1 ; TUNCEL, Jonatan3 ; ELIASSON, Lena1
[1] Lund University Diabetes Centre, Malmö, 20502 Malmö, Sweden
[2] Key Laboratory of Hormones and Development, Ministry of Health, China, Tianjin Metabolic Diseases Hospital, Tianjin Medical University, China
[3] Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stock- holm, Sweden
[4] Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom - Source
Science (Washington, D.C.). 2010, Vol 327, Num 5962, pp 217-220, 4 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste Diabète Exocytose Glucose Homme Insuline Membrane plasmique Polymorphisme Rat Récepteur adrénergique Récepteur biologique Surexpression génique Sécrétion Endocrinopathie Hormone pancréatique Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antagonist Diabetes mellitus Exocytosis Glucose Human Insulin Plasma membrane Polymorphism Rat Adrenergic receptor Biological receptor Gene overexpression Secretion Endocrinopathy Pancreatic hormone Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antagonista Diabetes Exocitosis Glucosa Hombre Insulina Membrana plasmática Polimorfismo Rata Receptor adrenérgico Receptor biológico Sobreexpresión genética Secreción Endocrinopatía Hormona pancreática Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A25 Vertebrates: nervous system and sense organs
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance
- Discipline
- Endocrinopathies Vertebrates : nervous system and sense organs
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22288868
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1126/science.1176827 
https://dx.doi.org/10.1126/science.1176827
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"327\";s:8:\"\u0000*\u0000issue\";s:4:\"5962\";s:8:\"\u0000*\u0000spage\";s:3:\"217\";s:8:\"\u0000*\u0000epage\";s:3:\"220\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:9:\"ROSENGREN\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Anders H\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:15:{i:0;s:16:\"JOKUBKA, Ramunas\";i:1;s:11:\"GROOP, Leif\";i:2;s:15:\"RORSMAN, Patrik\";i:3;s:14:\"SALEHI, Albert\";i:4;s:18:\"LYSSENKO, Valeriya\";i:5;s:15:\"LUTHMAN, Holger\";i:6;s:15:\"RENSTR\u00d6M, Erik\";i:7;s:13:\"TOJJAR, Damon\";i:8;s:19:\"GRANHALL, Charlotte\";i:9;s:12:\"HANSSON, Ola\";i:10;s:12:\"LI, Dai-Qing\";i:11;s:13:\"NAGARAJ, Vini\";i:12;s:19:\"REINBOTHE, Thomas M\";i:13;s:15:\"TUNCEL, Jonatan\";i:14;s:14:\"ELIASSON, Lena\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"327\";s:8:\"\u0000*\u0000issue\";s:4:\"5962\";s:8:\"\u0000*\u0000spage\";s:3:\"217\";s:8:\"\u0000*\u0000epage\";s:3:\"220\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:9:\"ROSENGREN\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Anders H\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:15:{i:0;s:16:\"JOKUBKA, Ramunas\";i:1;s:11:\"GROOP, Leif\";i:2;s:15:\"RORSMAN, Patrik\";i:3;s:14:\"SALEHI, Albert\";i:4;s:18:\"LYSSENKO, Valeriya\";i:5;s:15:\"LUTHMAN, Holger\";i:6;s:15:\"RENSTR\u00d6M, Erik\";i:7;s:13:\"TOJJAR, Damon\";i:8;s:19:\"GRANHALL, Charlotte\";i:9;s:12:\"HANSSON, Ola\";i:10;s:12:\"LI, Dai-Qing\";i:11;s:13:\"NAGARAJ, Vini\";i:12;s:19:\"REINBOTHE, Thomas M\";i:13;s:15:\"TUNCEL, Jonatan\";i:14;s:14:\"ELIASSON, Lena\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"327\";s:8:\"\u0000*\u0000issue\";s:4:\"5962\";s:8:\"\u0000*\u0000spage\";s:3:\"217\";s:8:\"\u0000*\u0000epage\";s:3:\"220\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:9:\"ROSENGREN\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Anders H\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:15:{i:0;s:16:\"JOKUBKA, Ramunas\";i:1;s:11:\"GROOP, Leif\";i:2;s:15:\"RORSMAN, Patrik\";i:3;s:14:\"SALEHI, Albert\";i:4;s:18:\"LYSSENKO, Valeriya\";i:5;s:15:\"LUTHMAN, Holger\";i:6;s:15:\"RENSTR\u00d6M, Erik\";i:7;s:13:\"TOJJAR, Damon\";i:8;s:19:\"GRANHALL, Charlotte\";i:9;s:12:\"HANSSON, Ola\";i:10;s:12:\"LI, Dai-Qing\";i:11;s:13:\"NAGARAJ, Vini\";i:12;s:19:\"REINBOTHE, Thomas M\";i:13;s:15:\"TUNCEL, Jonatan\";i:14;s:14:\"ELIASSON, Lena\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"327\";s:8:\"\u0000*\u0000issue\";s:4:\"5962\";s:8:\"\u0000*\u0000spage\";s:3:\"217\";s:8:\"\u0000*\u0000epage\";s:3:\"220\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:9:\"ROSENGREN\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Anders H\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:15:{i:0;s:16:\"JOKUBKA, Ramunas\";i:1;s:11:\"GROOP, Leif\";i:2;s:15:\"RORSMAN, Patrik\";i:3;s:14:\"SALEHI, Albert\";i:4;s:18:\"LYSSENKO, Valeriya\";i:5;s:15:\"LUTHMAN, Holger\";i:6;s:15:\"RENSTR\u00d6M, Erik\";i:7;s:13:\"TOJJAR, Damon\";i:8;s:19:\"GRANHALL, Charlotte\";i:9;s:12:\"HANSSON, Ola\";i:10;s:12:\"LI, Dai-Qing\";i:11;s:13:\"NAGARAJ, Vini\";i:12;s:19:\"REINBOTHE, Thomas M\";i:13;s:15:\"TUNCEL, Jonatan\";i:14;s:14:\"ELIASSON, Lena\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1176827\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"327\";s:8:\"\u0000*\u0000issue\";s:4:\"5962\";s:8:\"\u0000*\u0000spage\";s:3:\"217\";s:8:\"\u0000*\u0000epage\";s:3:\"220\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:9:\"ROSENGREN\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Anders H\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:15:{i:0;s:16:\"JOKUBKA, Ramunas\";i:1;s:11:\"GROOP, Leif\";i:2;s:15:\"RORSMAN, Patrik\";i:3;s:14:\"SALEHI, Albert\";i:4;s:18:\"LYSSENKO, Valeriya\";i:5;s:15:\"LUTHMAN, Holger\";i:6;s:15:\"RENSTR\u00d6M, Erik\";i:7;s:13:\"TOJJAR, Damon\";i:8;s:19:\"GRANHALL, Charlotte\";i:9;s:12:\"HANSSON, Ola\";i:10;s:12:\"LI, Dai-Qing\";i:11;s:13:\"NAGARAJ, Vini\";i:12;s:19:\"REINBOTHE, Thomas M\";i:13;s:15:\"TUNCEL, Jonatan\";i:14;s:14:\"ELIASSON, Lena\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
