Structure—Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections
- Author
- JIANGNAN PENG1 ; KUDRIMOTI, Sucheta1 ; KHAN, Shabana I1 3 ; BIN WANG1 ; MAYER, Alejandro M. S4 ; JACOB, Melissa R3 ; TU, Lan Chun5 ; GERTSCH, Jürg6 7 ; HAMANN, Mark T1 3 ; PRASANNA, Sivaprakasam2 ; ODDE, Srinivas2 ; DOERKSEN, Robert J1 3 ; PENNAKA, Hari K1 ; CHOO, Yeun-Mun1 ; RAO, Karumanchi V1 ; TEKWANI, Babu L3 ; MADGULA, Vamsi3
[1] Department of Pharmacognosy, The University of Mississippi, Oxford, Mississippi 38677, United States
[2] Department of Medicinal Chemistry, The University of Mississippi, Oxford, Mississippi 38677, United States
[3] National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, Mississippi 38677, United States
[4] Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, United States
[5] Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan, Province of China
[6] Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
[7] Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland - Source
Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 61-76, 16 p ; ref : 72 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Alcaloïde Animal Antibactérien Antifongique Antiinflammatoire Antipaludique Antiparasitaire Antiprotozoaire Barrière hématoencéphalique Inflammation Mode liaison Modèle moléculaire Modélisation Mécanisme action Phénols Relation structure activité Tau-protein kinase 9a,13-Méthanoazacycloundécino[3,2-e]azacyclopentadécine dérivé EC 2-7-11-26 Manzamine Méthanoazacycloundécinoazacyclopentadécine Pyrido[3,4-b]indole dérivé Pyridoindole Enzyme Transferases
- Keyword (en)
- Alkaloid Animal Antibacterial agent Antifungal agent Antiinflammatory agent Antimalarial Parasiticide Antiprotozoal agent Blood brain barrier Inflammation Binding mode Molecular model Modeling Mechanism of action Phenols Structure activity relation Tau-protein kinase Enzyme Transferases
- Keyword (es)
- Alcaloide Animal Antibacteriano Antifúngico Antiinflamatorio Antipalúdico Antiparasitario Antiprotozoario Barrera hematoencefálica Inflamación Modo de enlace Modelo molecular Modelización Mecanismo acción Fenoles Relación estructura actividad Tau-protein kinase Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S04 Antifungal agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22361871
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm900672t 
https://dx.doi.org/10.1021/jm900672t
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