Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 arginine Mimetics
- Author
- BECKER, Gero. L1 ; SIELAFF, Frank1 ; THAN, Manuel E2 ; LINDBERG, Iris3 ; ROUTHIER, Sophie1 ; DAY, Robert4 ; YINGHUI LU5 ; GARTEN, Wolfgang5 ; STEINMETZER, Torsten1
[1] Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, 35032 Marburg, Germany
[2] Leibniz Institute for Age Research-Fritz Lipmann Institute(FLI), Protein Crystallography Group, Beutenhergstrasse 11, 07745 Jena, Germany
[3] Department of Anatomy and Neurrobiology, Universily of Maryland, Baltimore, Maryland 21201, United States
[4] Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke. Québec, JIH 5N4, Canada
[5] Institule of Virology, Philipps University Marburg, Hans-Meerwein-Strasse 2, 35043 Marburg, Germany - Source
Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1067-1075, 9 p ; ref : 52 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Amidine Furin In vitro Inhibiteur enzyme Mimétique Mode liaison Modèle moléculaire Modélisation Peptide Synthèse chimique Tripeptide α-Aminoacide Arginine dérivé Benzamidine(4-[phénylacétyl-arginyl-valyl-argiinylaminométhyl]) Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (en)
- Biological activity Amidine Furin In vitro Enzyme inhibitor Mimetic Binding mode Molecular model Modeling Peptides Chemical synthesis Tripeptide α-Aminoacid Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (es)
- Actividad biológica Amidina Furin In vitro Inhibidor enzima Mimético Modo de enlace Modelo molecular Modelización Péptido Síntesis química Tripéptido α-Aminoácido Enzima Hydrolases Peptidases Serine endopeptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B11 Miscellaneous
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22454115
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9012455 
https://dx.doi.org/10.1021/jm9012455
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