Improved measurement of drug exposure in the brain using drug-specific correction for residual blood
- Author
- FRIDEN, Markus1 2 ; LJUNGQVIST, Helena3 ; MIDDLETON, Brian4 ; BREDBERG, Ulf2 ; HAMMARLUND-UDENAES, Margareta1
[1] Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
[2] Discovery Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, Mölndal, Sweden
[3] University of Gothenburg, Sweden
[4] Discovery Statistics Group, AstraZeneca R&D, Alderley Park, United Kingdom - Source
Journal of cerebral blood flow and metabolism. 2010, Vol 30, Num 1, pp 150-161, 12 p ; ref : 3/4 p
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- BBB (blood-brain barrier) CBV (cerebral blood volume) brain distribution (of neuroactive substances)
- Keyword (fr)
- Barrière hématoencéphalique Correction Encéphale Pathologie cérébrovasculaire Pathologie du système nerveux Volume sanguin Pathologie de l'encéphale Pathologie du système nerveux central
- Keyword (en)
- Blood brain barrier Corrections Encephalon Cerebrovascular disease Nervous system diseases Blood volume Cerebral disorder Central nervous system disease
- Keyword (es)
- Barrera hematoencefálica Corrección Encéfalo Vaso sanguíneo encéfalo patología Sistema nervioso patología Volumen sanguíneo Encéfalo patología Sistema nervosio central patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17C Vascular diseases and vascular malformations of the nervous system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B24 Investigative techniques, diagnostic techniques (general aspects) / 002B24C Ultrasonic investigative techniques / 002B24C03 Nervous system
- Discipline
- Neurology Scanning and diagnostic techniques
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22499642
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/jcbfm.2009.200 
https://dx.doi.org/10.1038/jcbfm.2009.200
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