Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens
- Author
- BAG, Seema1 ; TAWARI, Nilesh R1 ; DEGANI, Mariam S1 ; QUEENER, Sherry F2
[1] Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400 019, India
[2] Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 9, pp 3187-3197, 11 p ; ref : 28 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2,4-Diaminopyrimidine Dihydrofolate reductase Docking MM-GBSA
- Keyword (fr)
- Antibactérien Antifolate Antifongique Antiinfectieux Antimétabolite Antiparasitaire Antiprotozoaire Complexe enzyme inhibiteur Dihydrofolate reductase Dérivé de la pyrimidine In vitro Infection opportuniste Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Mycobacterium avium Pneumocystis carinii Relation structure activité Synthèse chimique Toxoplasma gondii Actinomycetes Apicomplexa Bactérie Enzyme Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Keyword (en)
- Antibacterial agent Antifolate Antifungal agent Antiinfectious Antimetabolic Parasiticide Antiprotozoal agent Inhibitor enzyme complex Dihydrofolate reductase Pyrimidine derivatives In vitro Opportunistic infection Enzyme inhibitor Binding mode Molecular model Modeling Mycobacterium avium Pneumocystis carinii Structure activity relation Chemical synthesis Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzyme Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Keyword (es)
- Antibacteriano Antifolato Antifúngico Antiinfeccioso Antimetabólito Antiparasitario Antiprotozoario Complejo enzima inhibidor Dihydrofolate reductase Pirimidina derivado In vitro Infección oportunista Inhibidor enzima Modo de enlace Modelo molecular Modelización Mycobacterium avium Pneumocystis carinii Relación estructura actividad Síntesis química Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzima Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S04 Antifungal agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22891292
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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