Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

Author

AGHAJAN, Mariam¹ ; NAO JONAI¹ ; DAMOISEAUX, Robert⁷ ; RUI HAO¹ ; DEL MORAL, Pierre M⁸ ; VERMA, Rati⁵ ; YING LI⁴ ; CHENG LI⁹ ; HOUK, Kendall N⁴ ; JUNG, Michael E⁴ ; NING ZHENG⁶ ; LAN HUANG¹⁰ ; FLICK, Karin² ; DESHAIES, Raymond J⁵ ; KAISER, Peter² ; JING HUANG¹ ; FEI FU¹ ; MANLIN LUO³ ; XIAOLU CAI⁴ ; OUNI, Ikram² ; PIERCE, Nathan⁵ ; XIAOBO TANG⁶ ; LOMENICK, Brett¹
[1] Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, and the Molecular Biology Institute, University of California, Los Angeles, California, United States
[2] Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, United States
[3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
[4] Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States
[5] Department of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, United States
[6] Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States
[7] Molecular Screening Shared Resource, University of California, Los Angeles, California, United States
[8] Roche Diagnostics Corporation, Roche Applied Science, Indianapolis, Indiana, United States
[9] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States
[10] Departments of Physiology & Biophysics and Developmental & Cell Biology, University of California, Irvine, California, United States

Source

Nature biotechnology (Print). 2010, Vol 28, Num 7, pp 738-742, 5 p ; ref : 29 ref

CODEN

NABIF9

ISSN

1087-0156

Scientific domain

Biotechnology

Publisher

Nature Publishing Group, New York, NY

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Anticancéreux Inhibiteur Ligases Sirolimus Cible de la rapamycine SCF family E3 ubiquitin ligase Enzyme

Keyword (en)

Antineoplastic agent Inhibitor Ligases Sirolimus Enzyme

Keyword (es)

Anticanceroso Inhibidor Ligases Sirolimús Enzima

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04B Diverse techniques

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01G Miscellaneous

Discipline

Biotechnology Molecular and cell biology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

23019293

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS