Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
- Author
- MEINDL, Alfons1 ; HELLEBRAND, Heide1 ; RAMSER, Juliane1 ; HONISCH, Ellen4 ; KUBISCH, Christian7 ; WICHMANN, Hans E8 ; KAST, Karin9 ; DEISSLER, Helmut10 ; ENGEL, Christoph11 ; MÜLLER-MYHSOK, Bertram12 ; NEVELING, Kornelia13 ; KIECHLE, Marion1 ; WIEK, Constanze2 ; MATHEW, Christopher G14 ; SCHINDLER, Detlev13 ; SCHMUTZLER, Rita K3 ; HANENBERG, Helmut15 2 ; ERVEN, Verena2 ; WAPPENSCHMIDT, Barbara3 ; NIEDERACHER, Dieter4 ; FREUND, Marcel2 ; LICHTNER, Peter5 ; HARTMANN, Linda6 ; SCHAAL, Heiner6
[1] Department of Obstetrics and Gynecology, Division of Tumor Genetics, Klinikum rechts der Isar der Technischen Universitaet Muenchen, Munich, Germany
[2] Department of Pediatric Hematology, Oncology and Clinical Immunology, Children's Hospital, Heinrich-Heine-University, Düsseldorf, Germany
[3] Center for Familial Breast and Ovarian Cancer and Center for Integrated Oncology, University Hospital, Cologne, Germany
[4] Department of Obstetrics and Gynecology, Heinrich-Heine-University, Düsseldorf, Germany
[5] Institute of Human Genetics, Helmholtz Zentrum Muenchen, Neuherberg, Germany
[6] Institute of Virology, Heinrich-Heine-University, Düsseldorf, Germany
[7] Institute of Human Genetics, Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany
[8] Institute of Epidemiology, Helmholtz Zentrum Muenchen, Neuherberg, Germany
[9] Department of Obstetrics and Gynecology, Carl Gustav Carus University, Dresden, Germany
[10] Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany
[11] Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
[12] Max-Planck-Institute of Psychiatry, Munich, Germany
[13] Department of Human Genetics, University of Würzburg, Würzburg, Germany
[14] Department of Medical and Molecular Genetics, Kings College, Guy's Hospital, London, United Kingdom
[15] Department of Pediatrics, Wells Center for Pediatric Research, Riley Hospital, Indiana University School of Medicine, Indianapolis, Indiana, United States - Source
Nature genetics. 2010, Vol 42, Num 5, pp 410-414, 5 p ; ref : 26 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancer de l'ovaire Cancer du sein Gène réparation Homme Lignée germinale Mutation Pedigree Sensibilité Tumeur maligne Cancer Pathologie de l'appareil génital femelle Pathologie de la glande mammaire Pathologie des ovaires Pathologie du sein
- Keyword (en)
- Ovary cancer Breast cancer Repair gene Human Germ line Mutation Pedigree Sensitivity Malignant tumor Cancer Female genital diseases Mammary gland diseases Ovarian diseases Breast disease
- Keyword (es)
- Cáncer del ovario Cáncer del pecho Gen reparación Hombre Línea germinal Mutación Pedigrí Sensibilidad Tumor maligno Cáncer Aparato genital hembra patología Glándula mamaria patología Ovario patología Seno patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20C Female genital diseases / 002B20C02 Tumors
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Gynecology. Andrology. Obstetrics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23092426
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.569 
https://dx.doi.org/10.1038/ng.569
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