Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin
- Author
- LI, G1 ; MISKIMEN, K. L1 ; WANG, Z1 ; XIE, X. Y2 ; TSE, W1 ; GOUILLEUX, F3 ; MORIGGL, R4 ; BUNTING, K. D1
[1] Division of Hematology-Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States
[2] Department of Pathology, Summa Health Barberton Hospital, Barberton, OH, United States
[3] INSERM, Department of Medicine, Universite de Picardie J. Verne, Amiens, France
[4] Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria - Source
Leukemia. 2010, Vol 24, Num 8, pp 1397-1405, 9 p ; ref : 39 ref
- CODEN
- LEUKED
- ISSN
- 0887-6924
- Scientific domain
- Medical oncology; Hematology
- Publisher
- Nature Publishing Group, Avenel, NJ
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- JAK/STAT cytokine signaling flow cytometry hematopoiesis hematopoietic stem cell leukemogenesis
- Keyword (fr)
- Anticancéreux Carcinogenèse Cellule hématopoïétique Cellule souche Ciblage Cytokine Cytométrie flux Efficacité Facteur transcription STAT5 Facteur transcription STAT Hématologie Hématopoïèse Leucémogenèse Sirolimus Survie Syndrome myéloprolifératif Transduction signal Inhibiteur mTOR Jak protein tyrosine kinase Hémopathie Inhibiteur synthèse protéique Lactone Macrocycle Macrolide
- Keyword (en)
- Antineoplastic agent Carcinogenesis Hematopoietic cell Stem cell Targeting Cytokine Flow cytometry Efficiency Transcription factor STAT5 Transduction factor STAT Hematology Hematopoiesis Leukemogenesis Sirolimus Survival Myeloproliferative syndrome Signal transduction Jak protein tyrosine kinase Hemopathy Protein synthesis inhibitor Lactone Macrocycle Macrolide
- Keyword (es)
- Anticanceroso Carcinogénesis Célula hematopoyética Célula primitiva Blancado Citoquina Citometría flujo Eficacia Factor transcripción STAT5 Factor transcripción STAT Hematología Hematopoyesis Leucemogénesis Sirolimús Sobrevivencia Mieloproliferativo síndrome Transducción señal Jak protein tyrosine kinase Hemopatía Inhibidor síntesis proteica Lactona Macrociclo Macrólido
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23098782
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/leu.2010.131 
https://dx.doi.org/10.1038/leu.2010.131
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