Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- Author
- FLAHERTY, Keith T1 2 ; PUZANOV, Igor3 ; CHAPMAN, Paul B9 ; KIM, Kevin B4 ; RIBAS, Antoni5 ; MCARTHUR, Grant A6 ; SOSMAN, Jeffrey A3 ; O'DWYER, Peter J1 ; LEE, Richard J7 ; GRIPPO, Joseph F7 ; NOLOP, Keith8
[1] Abramson Cancer Center of the University of Pennsylvania, Philadelphia, United States
[2] Massachusetts General Hospital Cancer Center, Boston, United States
[3] Vanderbilt University, Nashville, United States
[4] University of Texas M.D. Anderson Cancer Center, Houston, United States
[5] UCLA, Los Angeles, United States
[6] Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia
[7] Roche Pharmaceuticals, Nutley, NJ, United States
[8] Plexxikon, Berkeley, CA, United States
[9] Memorial Sloan-KetteringCancerCenter, NewYork, United States - Source
The New England journal of medicine. 2010, Vol 363, Num 9, pp 809-819, 11 p ; ref : 29 ref
- CODEN
- NEJMAG
- ISSN
- 0028-4793
- Scientific domain
- General medicine general surgery
- Publisher
- Massachusetts Medical Society, Waltham, MA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Gène onc cellulaire Inhibiteur Inhibition Mutation Médecine Mélanome malin Métastase Métastatique Protooncogène Stade avancé Gène BRAF Cancer Tumeur maligne
- Keyword (en)
- C-Onc gene Inhibitor Inhibition Mutation Medicine Malignant melanoma Metastasis Metastatic Protooncogene Advanced stage BRAF Gene Cancer Malignant tumor
- Keyword (es)
- Gen onc celular Inhibidor Inhibición Mutación Medicina Melanoma maligno Metástasis Metastásico Protooncogen Estadio avanzado Gen BRAF Cáncer Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology / 002B08A Tumors of the skin and soft tissue. Premalignant lesions
- Discipline
- Dermatology Generalities in medical sciences
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23146863
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1056/NEJMoa1002011 
https://dx.doi.org/10.1056/NEJMoa1002011
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:9:\"\u0000*\u0000jtitle\";s:35:\"The New England journal of medicine\";s:9:\"\u0000*\u0000stitle\";s:15:\"N. Engl. j. med\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"363\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:3:\"809\";s:8:\"\u0000*\u0000epage\";s:3:\"819\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-4793\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"FLAHERTY\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Keith T\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:10:{i:0;s:13:\"PUZANOV, Igor\";i:1;s:15:\"CHAPMAN, Paul B\";i:2;s:12:\"KIM, Kevin B\";i:3;s:13:\"RIBAS, Antoni\";i:4;s:17:\"MCARTHUR, Grant A\";i:5;s:17:\"SOSMAN, Jeffrey A\";i:6;s:16:\"O'DWYER, Peter J\";i:7;s:14:\"LEE, Richard J\";i:8;s:16:\"GRIPPO, Joseph F\";i:9;s:12:\"NOLOP, Keith\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NEJMAG\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:8:\"\u0000*\u0000place\";s:11:\"Waltham, MA\";s:6:\"\u0000*\u0000pub\";s:29:\"Massachusetts Medical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"11\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:9:\"\u0000*\u0000jtitle\";s:35:\"The New England journal of medicine\";s:9:\"\u0000*\u0000stitle\";s:15:\"N. Engl. j. med\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"363\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:3:\"809\";s:8:\"\u0000*\u0000epage\";s:3:\"819\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-4793\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"FLAHERTY\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Keith T\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:10:{i:0;s:13:\"PUZANOV, Igor\";i:1;s:15:\"CHAPMAN, Paul B\";i:2;s:12:\"KIM, Kevin B\";i:3;s:13:\"RIBAS, Antoni\";i:4;s:17:\"MCARTHUR, Grant A\";i:5;s:17:\"SOSMAN, Jeffrey A\";i:6;s:16:\"O'DWYER, Peter J\";i:7;s:14:\"LEE, Richard J\";i:8;s:16:\"GRIPPO, Joseph F\";i:9;s:12:\"NOLOP, Keith\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NEJMAG\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:8:\"\u0000*\u0000place\";s:11:\"Waltham, MA\";s:6:\"\u0000*\u0000pub\";s:29:\"Massachusetts Medical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"11\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:9:\"\u0000*\u0000jtitle\";s:35:\"The New England journal of medicine\";s:9:\"\u0000*\u0000stitle\";s:15:\"N. Engl. j. med\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"363\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:3:\"809\";s:8:\"\u0000*\u0000epage\";s:3:\"819\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-4793\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"FLAHERTY\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Keith T\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:10:{i:0;s:13:\"PUZANOV, Igor\";i:1;s:15:\"CHAPMAN, Paul B\";i:2;s:12:\"KIM, Kevin B\";i:3;s:13:\"RIBAS, Antoni\";i:4;s:17:\"MCARTHUR, Grant A\";i:5;s:17:\"SOSMAN, Jeffrey A\";i:6;s:16:\"O'DWYER, Peter J\";i:7;s:14:\"LEE, Richard J\";i:8;s:16:\"GRIPPO, Joseph F\";i:9;s:12:\"NOLOP, Keith\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NEJMAG\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:8:\"\u0000*\u0000place\";s:11:\"Waltham, MA\";s:6:\"\u0000*\u0000pub\";s:29:\"Massachusetts Medical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"11\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:9:\"\u0000*\u0000jtitle\";s:35:\"The New England journal of medicine\";s:9:\"\u0000*\u0000stitle\";s:15:\"N. Engl. j. med\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"363\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:3:\"809\";s:8:\"\u0000*\u0000epage\";s:3:\"819\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-4793\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"FLAHERTY\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Keith T\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:10:{i:0;s:13:\"PUZANOV, Igor\";i:1;s:15:\"CHAPMAN, Paul B\";i:2;s:12:\"KIM, Kevin B\";i:3;s:13:\"RIBAS, Antoni\";i:4;s:17:\"MCARTHUR, Grant A\";i:5;s:17:\"SOSMAN, Jeffrey A\";i:6;s:16:\"O'DWYER, Peter J\";i:7;s:14:\"LEE, Richard J\";i:8;s:16:\"GRIPPO, Joseph F\";i:9;s:12:\"NOLOP, Keith\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NEJMAG\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:8:\"\u0000*\u0000place\";s:11:\"Waltham, MA\";s:6:\"\u0000*\u0000pub\";s:29:\"Massachusetts Medical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"11\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:21:\"10.1056\/NEJMoa1002011\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:9:\"\u0000*\u0000jtitle\";s:35:\"The New England journal of medicine\";s:9:\"\u0000*\u0000stitle\";s:15:\"N. Engl. j. med\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:3:\"363\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:3:\"809\";s:8:\"\u0000*\u0000epage\";s:3:\"819\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-4793\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:8:\"FLAHERTY\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Keith T\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:10:{i:0;s:13:\"PUZANOV, Igor\";i:1;s:15:\"CHAPMAN, Paul B\";i:2;s:12:\"KIM, Kevin B\";i:3;s:13:\"RIBAS, Antoni\";i:4;s:17:\"MCARTHUR, Grant A\";i:5;s:17:\"SOSMAN, Jeffrey A\";i:6;s:16:\"O'DWYER, Peter J\";i:7;s:14:\"LEE, Richard J\";i:8;s:16:\"GRIPPO, Joseph F\";i:9;s:12:\"NOLOP, Keith\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NEJMAG\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:60:\"Inhibition of Mutated, Activated BRAF in Metastatic Melanoma\";s:8:\"\u0000*\u0000place\";s:11:\"Waltham, MA\";s:6:\"\u0000*\u0000pub\";s:29:\"Massachusetts Medical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"11\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
