Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene
- Author
- NISHIOKA, C1 2 ; IKEZOE, T1 ; YANG, J1 ; YOKOYAMA, A1
[1] Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan
[2] Japanese Society for the Promotion of Science (JSPS), Tokyo, Japan - Source
Leukemia. 2010, Vol 24, Num 9, pp 1631-1640, 10 p ; ref : 48 ref
- CODEN
- LEUKED
- ISSN
- 0887-6924
- Scientific domain
- Medical oncology; Hematology
- Publisher
- Nature Publishing Group, Avenel, NJ
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- AKT ERK PTEN STAT5 imatinib
- Keyword (fr)
- Akt protein kinase Anticancéreux Exposition Extracellular signal-regulated protein kinase Facteur transcription STAT5 Gène PTEN Gène suppresseur tumeur Hématologie Imatinib Inhibiteur multikinase Leucémie Long terme Mitogen-activated protein kinase Silence expression génique Transduction signal Silence épigénétique Cancer Enzyme Hémopathie maligne Inhibiteur de la tyrosine kinase Inhibiteur enzyme Protein-tyrosine kinase Transferases
- Keyword (en)
- Akt protein kinase Antineoplastic agent Exposure Extracellular signal-regulated protein kinase Transcription factor STAT5 PTEN Gene Tumor suppressor gene Hematology Imatinib Multikinase inhibitor Leukemia Long term Mitogen-activated protein kinase Gene silencing Signal transduction Epigenetic silencing Cancer Enzyme Malignant hemopathy Tyrosine kinase inhibitor Enzyme inhibitor Protein-tyrosine kinase Transferases
- Keyword (es)
- Akt protein kinase Anticanceroso Exposición Extracellular signal-regulated protein kinase Factor transcripción STAT5 Gen PTEN Gen supresor tumor Hematología Imatinib inhibidor multicinasa Leucemia Largo plazo Mitogen-activated protein kinase Silencio expresión genética Transducción señal Cáncer Enzima Hemopatía maligna Inhibidor tyrosine kinase Inhibidor enzima Protein-tyrosine kinase Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23234707
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/leu.2010.145 
https://dx.doi.org/10.1038/leu.2010.145
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