A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

Author

HEINIG, Matthias^{1 2} ; PETRETTO, Enrico^{3 4} ; HUMMEL, Oliver¹ ; LEEL, Young-Ae^{1 7} ; PASKAS, Svetlana¹ ; RINTISCH, Carola¹ ; SAAR, Kathrin¹ ; COOPER, Jason⁵ ; BUCHAN, Rachel³ ; GRAY, Elizabeth E⁸ ; CYSTER, Jason G⁸ ; CONSORTIUM, Cardiogenics; WALLACE, Chris⁵ ; ERDMANN, Jeanette⁹ ; HENGSTENBERG, Christian¹⁰ ; MAOUCHE, Seraya⁶ ; OUWEHAND, Willem H^{11 12} ; RICE, Catherine M¹² ; SAMANI, Nilesh J¹³ ; SCHUNKERT, Heribert⁹ ; GOODALL, Alison H¹³ ; SCHULZ, Herbert¹ ; ROIDER, Helge G² ; BOTTOLO, Leonardo^{3 4} ; VINGRON, Martin² ; BLANKENBERG, Stefan¹⁴ ; MÜNZEL, Thomas¹⁴ ; ZELLER, Tanja¹⁴ ; SZYMCZAK, Silke¹⁵ ; ZIEGLER, Andreas¹⁵ ; TIRET, Laurence⁶ ; SMYTH, Deborah J⁵ ; PRAVENEC, Michal¹⁶ ; AITMAN, Timothy J³ ; ROTIVAL, Maxime⁶ ; CAMBIEN, Francois⁶ ; CLAYTON, David⁵ ; TODD, John A⁵ ; HUBNER, Norbert^{1 17} ; COOK, Stuart A^{18 3} ; HAN LU³ ; YOYO LI³ ; SARWAR, Rizwan³ ; LANGLEY, Sarah R³ ; BAUERFEIND, Anja¹
[1] Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125 Berlin, Germany
[2] Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany
[3] Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
[4] Department of Epidemiology and Biostatistics, Faculty of Medicine, Imperial College London, Praed Street, London W2 1 PG, United Kingdom
[5] Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, United Kingdom
[6] INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School, 91 Boulevard de l'Hôpital, Paris 75013, France
[7] Pediatric Pneumology and Immunology, Charité-Universitätsmedizin Berlin, Augusten burger Platz 1, 13353 Berlin, Germany
[8] Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, California 94143, United States
[9] Universität zu Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany
[10] Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, 93053 Regensburg, Germany
[11] Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge CB2 0PT, United Kingdom
[12] Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1SA, United Kingdom
[13] Department of Cardiovascular Sciences, University of Leicester and Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, United Kingdom
[14] Medizinische Klinik und Poliklinik, Johannes-Gutenberg Universität Mainz, Universltätsmedizin, Langenbeckstrasse 1, 55131 Mainz, Germany
[15] Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Maria-Goeppert-Strasse 1, 23562 Lübeck, Germany
[16] Institute of Physiology, Czech Academy of Sciences and Centre for Applied Genomics, Videnska 1083, 14220 Prague, Czech Republic
[17] CC4. Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
[18] National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom

Source

Nature (London). 2010, Vol 467, Num 7314, pp 460-464, 5 p ; ref : 29 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Antiviral Diabète de type 1 Locus Rat Risque Régulation Réseau de gènes Endocrinopathie Immunopathologie Maladie autoimmune Mammalia Rodentia Vertebrata

Keyword (en)

Antiviral Type 1 diabetes Locus Rat Risk Regulation(control) Endocrinopathy Immunopathology Autoimmune disease Mammalia Rodentia Vertebrata

Keyword (es)

Antiviral Diabetes de tipo 1 Locus Rata Riesgo Regulación Endocrinopatía Inmunopatología Enfermedad autoinmune Mammalia Rodentia Vertebrata

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution / 002A07C Classical genetics, quantitative genetics, hybrids / 002A07C01 Animals / 002A07C01B Vertebrata

Discipline

Eukaryotes genetics. Biological and molecular evolution

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

23234989

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS