Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Author

HOR, Hyun^{1 2} ; KUTALIK, Zoltán^{3 4} ; OVEREEM, Sebastiaan^{11 12} ; ARNULF, Isabelle¹³ ; THEODOROU, Ioannis¹⁴ ; JENNUM, Poul¹⁵ ; KNUDSEN, Stine¹⁵ ; BASSETTI, Claudio¹⁶ ; MATHIS, Johannes¹⁷ ; LECENDREUX, Michel¹⁸ ; MAYER, Geert¹⁹ ; GEISLER, Peter²⁰ ; DAUVILLIERS, Yves^{2 5} ; BENETO, Antonio²¹ ; PETIT, Brice¹ ; PFISTER, Corinne¹ ; VIENNE BÜRKI, Julie¹ ; DIDELOT, Gérard¹ ; BILLIARD, Michel⁵ ; ERCILLA, Guadalupe²² ; VERDUIJN, Willem²³ ; CLAAS, Frans H. J²³ ; VOLLENWIDER, Peter²⁴ ; VALSESIA, Armand^{3 4 6} ; WAEBER, Gerard²⁴ ; WATERWORTH, Dawn M²⁵ ; MOOSER, Vincent²⁵ ; HEINZER, Raphaël²⁶ ; BECKMANN, Jacquess^{27 3} ; BERGMANN, Sven^{3 4} ; TAFTI, Mehdi^{1 26} ; LAMMERS, Gert J⁷ ; DONJACOUR, Claire E. H. M⁷ ; IRANZO, Alex⁸ ; SANTAMARIA, Joan⁸ ; PERAITA ADRADOS, Rosa⁹ ; VICARIO, José L¹⁰
[1] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
[2] Institut National de la Santé et de la Recherche Médicale U888, Montpellier, France
[3] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
[4] Swiss Institute of Bioinformatics, Lausanne, Switzerland
[5] National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Department of Neurology, Gui-de-Chauliac Hospital, Montpellier, France
[6] Ludwig Institute for Cancer Research, Lausanne, Switzerland
[7] Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands
[8] Neurology Service, Hospital Clínic, Institut d'investigació Biomèdiques August Pi i Sunyer, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain
[9] Sleep and Epilepsy Unit, Clinical Neurophysiology Department, Gregorio Marañón University Hospital, Madrid, Spain
[10] Histocompatibility, Blood Center of the Community of Madrid, Madrid, Spain
[11] Sleep Medicine Center 'Kempenhaeghe', Heeze, Netherlands
[12] Department of Neurology, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
[13] National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Sleep Disorders Unit, Pitié-Salpêtrière Hospital, Paris, France
[14] Institut National de la Santé et de la Recherche Médicale U543, Pitié-Salpêtrière Hospital, Paris, France
[15] Department of Clinical Neurophysiology, University of Copenhagen, Glostrup, Denmark
[16] Neurocentro (Ente ospedaliero cantonale) della Svizzera Italiana, Ospedale Civico, Lugano, Switzerland
[17] Abteilung Klinische Neurophysiologie, Inselspital, Bern, Switzerland
[18] Pediatric Sleep Center, National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Department of Child and Adolescent Psychopathology, Robert Debré Hospital, Paris VII University, Paris, France
[19] Hephata-Clinic for Neurology, Schwalmstadt-Treys, Germany
[20] Sleep Disorders and Research Center, Department of Psychiatry and Psychotherapy, University Hospital Regensburg, Regensburg, Germany
[21] Unidad de Sueño, Servicio Neurofisiología Clinica, Hospital Universitario La Fe, Valencia, Spain
[22] Immunology Service, Institut d'investigació Biomèdiques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
[23] Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands
[24] Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
[25] Division of Genetics, Research and Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States
[26] Center for Investigation and Research in Sleep, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
[27] Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Source

Nature genetics. 2010, Vol 42, Num 9, pp 786-789, 4 p ; ref : 19 ref

CODEN

NGENEC

ISSN

1061-4036

Scientific domain

Genetics

Publisher

Nature Publishing Group, New York, NY

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Antigène histocompatibilité classe II Association Haplotype Identification Narcolepsie Echelle du génome Pathologie du système nerveux Trouble du sommeil Trouble neurologique

Keyword (en)

Class II histocompatibility antigen Association Haplotype Identification Narcolepsy Nervous system diseases Sleep disorder Neurological disorder

Keyword (es)

Antígeno histocompatibilidad clase II Asociación Haplotipo Identificación Narcolepsia Sistema nervioso patología Trastorno sueño Trastorno neurológico

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17A Nervous system (semeiology, syndromes) / 002B17A02 Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes

Discipline

Eukaryotes genetics. Biological and molecular evolution Neurology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

23247798

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS