Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: Application to the study of cocaine metabolism in human primary cultured renal cells
- Author
- VALENTE, Maria João1 ; CARVALHO, Félix1 ; BASTOS, M. Lourdes1 ; CARVALHO, Márcia1 2 ; GUEDES DE PINHO, Paula1
[1] REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
[2] CEBIMED/Research Group on Toxicology and Phytochemistry, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal - Source
Journal of chromatography. B. 2010, Vol 878, Num 30, pp 3083-3088, 6 p ; ref : 42 ref
- ISSN
- 1570-0232
- Scientific domain
- Medical laboratory techniques; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Cocaine GC/IT-MS Human proximal tubular cells Metabolites
- Keyword (fr)
- Alcaloïde Analyse chimique Analyse quantitative Cocaïne Culture cellulaire Dérivé du tropane Développement Ecgonine(O-benzoyl) Homme In vitro Mesure simultanée Métabolisme Métabolite Piège ion Proximal Rein Substance toxicomanogène Validation 8-Azabicyclo[3.2.1]octane dérivé GC MS Spectrométrie masse tandem Appareil urinaire Ester Pharmacocinétique
- Keyword (en)
- Alkaloid Chemical analysis Quantitative analysis Cocaine Cell culture Tropane derivatives Development Human In vitro Simultaneous measurement Metabolism Metabolite Ion trap Proximal Kidney Drug of abuse Validation Tandem mass spectrometry Urinary system Ester Pharmacokinetics
- Keyword (es)
- Alcaloide Análisis químico Análisis cuantitativo Cocaína Cultivo celular Desarrollo Hombre In vitro Medición simultánea Metabolismo Metabolito Trampa ión Proximal Riñón Sustancia toxicomanógena Validación Espectrometría masa en tándem Aparato urinario Ester Farmacocinética
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23382659
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.jchromb.2010.09.010 
https://dx.doi.org/10.1016/j.jchromb.2010.09.010
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