Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies
- Author
- DRAGOVICH, P. S1 ; WEBBER, S. E1 ; LITTLEFIELD, E. S1 ; ZHOU, R1 ; TIKHE, J1 ; FORD, C. E1 ; WALLACE, M. B1 ; MEADOR, J. W1 ; FERRE, R. A1 ; BROWN, E. L1 ; BINFORD, S. L1 ; HARR, J. E. V1 ; BABINE, R. E1 ; DELISLE, D. M2 ; WORLAND, S. T2 ; FUHRMAN, S. A1 ; PATICK, A. K1 ; MATTHEWS, D. A1 ; LEE, C. A1 ; REICH, S. H1 ; PRINS, T. J1 ; MARAKOVITS, J. T1
[1] Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, United States
[2] Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, United States - Source
Journal of medicinal chemistry (Print). 1998, Vol 41, Num 15, pp 2806-2818 ; ref : 42 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antiviral Carboxamide Complexe enzyme inhibiteur Composé vinylique Diacide carboxylique Dipeptide Homme In vitro Inhibiteur enzyme Peptide Picornain 3C Rat Relation structure activité Rhinovirus humain Stabilité Structure cristalline Synthèse chimique Hex-2-ènedioïque acide(4-[benzyloxycarbonylleucyl-phénylalanylamino])-6-amide ester 1-éthyle Cysteine endopeptidases Enzyme Hydrolases Mammalia Peptidases Picornaviridae Rhinovirus Rodentia Vertebrata Virus
- Keyword (en)
- Animal Antiviral Carboxamide Inhibitor enzyme complex Vinylic compound Dicarboxylic acid Dipeptides Human In vitro Enzyme inhibitor Peptides Picornain 3C Rat Structure activity relation Human rhinovirus Stability Crystalline structure Chemical synthesis Cysteine endopeptidases Enzyme Hydrolases Mammalia Peptidases Picornaviridae Rhinovirus Rodentia Vertebrata Virus
- Keyword (es)
- Animal Antiviral Carboxamida Complejo enzima inhibidor Compuesto vinílico Diácido carboxílico Dipéptido Hombre In vitro Inhibidor enzima Péptido Picornain 3C Rata Relación estructura actividad Human rhinovirus Estabilidad Estructura cristalina Síntesis química Cysteine endopeptidases Enzima Hydrolases Mammalia Peptidases Picornaviridae Rhinovirus Rodentia Vertebrata Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2341030
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm980068d 
https://dx.doi.org/10.1021/jm980068d
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