Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
- Author
- IGAWA, Tomoyuki1 ; ISHII, Shinya1 ; WAKABAYASHI, Tetsuya1 ; HAYASAKA, Akira1 ; KADONO, Shoujiro1 ; MIYAZAKI, Takuya1 ; HARAYA, Kenta1 ; SEKIMORI, Yasuo1 ; KOJIMA, Tetsuo1 ; NABUCHI, Yoshiaki1 ; ASO, Yoshinori1 ; KAWABE, Yoshiki1 ; TACHIBANA, Tatsuhiko1 ; HATTORI, Kunihiro; MAEDA, Atsuhiko1 ; HIGUCHI, Yoshinobu1 ; SHIMAOKA, Shin1 ; MORIYAMA, Chifumi1 ; WATANABE, Tomoyuki1 ; TAKUBO, Ryoko1 ; DOI, Yoshiaki1
[1] Chugai Pharmaceutical Co. Ltd., Fuji-Gotemba Research Laboratories, Shizuoka, Japan - Source
Nature biotechnology (Print). 2010, Vol 28, Num 11, pp 1203-1207, 5 p ; ref : 24 ref
- CODEN
- NABIF9
- ISSN
- 1087-0156
- Scientific domain
- Biotechnology
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticorps monoclonal Antigène Biomédicament Mutation Neutralisation Pharmacocinétique Recyclage Site fixation Tocilizumab pH Médicament
- Keyword (en)
- Monoclonal antibody Antigen Biopharmaceuticals Mutation Neutralization Pharmacokinetics Recycling Binding site Tocilizumab pH Drug
- Keyword (es)
- Anticuerpo monoclonal Antígeno Biomedicamento Mutación Neutralización Farmacocinética Reconversión Sitio fijación Tocilizumab pH Medicamento
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01C Production of active biomolecules / 002A31D01C5 Monoclonal antibodies
- Discipline
- Biotechnology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23436193
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nbt.1691 
https://dx.doi.org/10.1038/nbt.1691
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