Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
- Author
- WERTZ, Ingrid E1 ; KUSAM, Saritha1 ; BELMONT, Lisa D4 ; KAMINKER, Joshua S5 ; O'ROURKE, Karen M6 ; PUJARA, Kanan7 ; BIR KOHLI, Pawan8 ; JOHNSON, Adam R8 ; CHIU, Mark L9 ; LILL, Jennie R3 ; JACKSON, Peter K4 ; FAIRBROTHER, Wayne J1 ; LAM, Cynthia1 ; SESHAGIRI, Somasekar7 ; LUDLAM, Mary J. C4 ; LEONG, Kevin G4 ; DUEBER, Erin C1 ; MAECKER, Heather4 ; HUANG, David C. S10 2 ; DIXIT, Vishva M6 ; OKAMOTO, Toru2 ; SANDOVAL, Wendy3 ; ANDERSON, Daniel J4 ; HELGASON, Elizabeth1 ; ERNST, James A1 3 ; EBY, Mike4 ; JINFENG LIU5
[1] Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, United States
[2] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
[3] Department of Protein Chemistry, Genentech, South San Francisco, California 94080, United States
[4] Department of Research Oncology, Genentech, South San Francisco, California 94080, United States
[5] Department of Bioinformatics, Genentech, South San Francisco, California 94080, United States
[6] Department of Physiological Chemistry, Genentech, South San Francisco, California 94080, United States
[7] Department of Molecular Biology, Genentech, South San Francisco, California 94080, United States
[8] Department of Biochemical Pharmacology, Genentech, South San Francisco, California 94080, United States
[9] Department of Structural Biology, Abbott Laboratories, Abbott Park, Illinois 60064, United States
[10] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia - Source
Nature (London). 2011, Vol 471, Num 7336, pp 110-114, 5 p ; ref : 20 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Adénocarcinome de l'ovaire Antitubuline Apoptose Cancer de l'ovaire Cancer du poumon Cancer du sein Carcinome non petite cellule bronchopulmonaire Cellule tumorale Chimiothérapie Cible Facteur prédictif Homme In vitro Leucémie Lymphome Microtubule Mitose Mort cellulaire Polymorphisme Protéine inhibitrice de l'apoptose Résistance traitement Sensibilité Taxol Thérapeutique ciblée Vincristine Gène MCL1 Gène hCDC4 Hémopathie maligne lymphoïde Traitement
- Keyword (en)
- Ovary adenocarcinoma Antitubulin Apoptosis Ovary cancer Lung cancer Breast cancer non-small cell lung carcinoma Tumor cell Chemotherapy Target Predictive factor Human In vitro Leukemia Lymphoma Microtubule Mitosis Cell death Polymorphism Apoptosis inhibitory protein Treatment resistance Sensitivity Taxol Targeted therapy Vincristine MCL1 gene Lymphoid neoplasm Treatment
- Keyword (es)
- Adenocarcinoma de ovario Antitubulina Apoptosis Cáncer del ovario Cáncer del pulmón Cáncer del pecho Carcinoma no pequeňa célula bronchopulmonar Célula tumoral Quimioterapia Blanco Factor predictivo Hombre In vitro Leucemia Linfoma Microtúbulo Mitosis Muerte celular Polimorfismo Proteína inhibidora de la apoptosis Resistencia tratamiento Sensibilidad Taxol Terapéutica dirigida Vincristina Tratamiento
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23891318
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature09779 
https://dx.doi.org/10.1038/nature09779
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