Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch Syndrome
- Author
- BONADONA, Valérie1 2 ; BONAITI, Bernard4 ; COLAS, Chrystelle14 ; NOGUES, Catherine15 ; LEJEUNE-DUMOULIN, Sophie16 ; OLIVIER-FAIVRE, Laurence17 ; POLYCARPE-OSAER, Florence18 ; DAT NGUYEN, Tan; DESSEIGNE, Françoise2 ; SAURIN, Jean-Christophe19 ; BERTHET, Pascaline20 ; LEROUX, Dominique21 ; OLSCHWANG, Sylviane5 6 ; DUFFOUR, Jacqueline22 ; MANOUVRIER, Sylvie16 ; FREBOURG, Thierry23 24 ; SOBOL, Hagay25 5 ; LASSET, Christine1 2 ; BONAÏTI-PELLIE, Catherine3 ; GRANDJOUAN, Sophie7 ; HUIART, Laetitia5 6 8 ; LONGY, Michel9 ; GUIMBAUD, Rosine10 ; BUECHER, Bruno11 ; BIGNON, Yves-Jean12 ; CARON, Olivier13
[1] Université Lyon 1, Centre National de la Recherche Scientifique (CNRS) UMR 5558, Villeurbanne, France
[2] Centre Leon Bérard, Lyon, France
[3] Institut National de la Sante et de la Recherche Medicale (INSERM), U669, Villejuif, France
[4] Institut National de la Recherche Agronomique (INRA)-GABI, Jouy-en-Josas, France
[5] Institut Paoli-Calmettes, Marseille, France
[6] INSERM, U891, Marseille, France
[7] Assistance Publique-Hopitaux de Paris (APHP) Cochin, Paris, France
[8] INSERM UMR 912, Marseille, France
[9] Institut Bergonié, Bordeaux, France
[10] Institut Claudius Regaud and Centre Hospitalier Universitaire (CHU), Toulouse, France
[11] CHU, Nantes, France
[12] Centre Jean Perrin, Clermont-Ferrand, France
[13] Institut Gustave Roussy, Villejuif, France
[14] APHP Groupe Hospitalier de la Pitié-Salpétrière, INSERM UMRS 938, and Université Pierre et Marie Curie, Paris, France
[15] Institut Curie, Hôpital René Huguenin, Saint-Cloud, France
[16] Centre Hospitalier Regional Universitaire (CHRU), and Université Lille 2, Lille, France
[17] Hôpital d'Enfants, Dijon, France
[18] Centre Paul Strauss, Strasbourg (Dr Polycarpe-Osaer); InstitutJean Godinot, Reims, France
[19] Hopital Edouard Her-riot, Lyon, France
[20] Centre François Baclesse, Caen, France
[21] CHU de Grenoble, Grenoble, France
[22] Centre Val d'Aurelle, Montpellier, France
[23] INSERM, U614, Rouen, France
[24] CHU, Rouen, France
[25] Université de la Méditerranée, Aix-Marseille II, Marseille, France - Source
JAMA, the journal of the American Medical Association. 2011, Vol 305, Num 22, pp 2304-2310, 7 p ; ref : 36 ref
- ISSN
- 0098-7484
- Scientific domain
- General medicine general surgery
- Publisher
- American Medical Association, Chicago, IL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Association Cancer colorectal héréditaire non polyposique Facteur risque Génétique Lignée germinale Mutation Médecine Risque Tumeur maligne Gène MLH1 Gène MSH2 Gène MSH6 Cancer Maladie héréditaire Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum
- Keyword (en)
- Association Hereditary nonpolyposis colorectal cancer Risk factor Genetics Germ line Mutation Medicine Risk Malignant tumor Cancer Genetic disease Digestive diseases Intestinal disease Colonic disease Rectal disease
- Keyword (es)
- Asociación Cáncer colorectal hereditario no poliposico Factor riesgo Genética Línea germinal Mutación Medicina Riesgo Tumor maligno Cáncer Enfermedad hereditaria Aparato digestivo patología Intestino patología Colón patología Recto patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Generalities in medical sciences
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24219792
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1001/jama.2011.743 
https://dx.doi.org/10.1001/jama.2011.743
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