Sorafenib in combination with erlotinib or with gemcitabine in elderly patients with advanced non-small-cell lung cancer: a randomized phase II study
- Author
- GRIDELLI, C1 ; MORGILLO, F2 ; PASELLO, G3 ; RICCIARDI, S4 ; MAIONE, P1 ; DI MAIO, M9 ; CIARDIELLO, F2 ; FAVARETTO, A3 ; DE MARINIS, F4 ; CHELLA, A5 ; CEREA, G6 ; MATTIOLI, R7 ; TORTORA, G8 ; ROSSI, A1 ; FASANO, M2
[1] Division of Medical Oncology, S.G. Moscati Hospital, Avellino, Italy
[2] Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, Second University of Naples, Naples, Italy
[3] Division of Medical Oncology II, Istituto Oncologico Veneto, Padua, Italy
[4] Thoracic-Oncology Unit 1st, Lung Diseases Department, San Camillo Hospital, Rome, Italy
[5] Pulmonary Unit, University Hospital of Pisa, Pisa, Italy
[6] The Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, Milan, Italy
[7] Medical Oncology Unit, S. Croce Hospital, Fano, Italy
[8] Medical Oncology Unit, Department of Molecular and Clinical Endocrinology, University of Naples Federico II, Italy
[9] Clinical Trials Unit, National Cancer Institute, Naples, Italy - Source
Annals of oncology. 2011, Vol 22, Num 7, pp 1528-1534, 7 p ; ref : 25 ref
- ISSN
- 0923-7534
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Oxford University Press, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- NSCLC elderly erlotinib gemcitabine sorafenib
- Keyword (fr)
- Antiangiogénique Anticancéreux Association médicamenteuse Cancer du poumon Carcinome non petite cellule bronchopulmonaire Chimiothérapie Erlotinib Essai clinique phase II Gemcitabine Malade Médicament Personne âgée Randomisation Sorafénib Stade avancé Traitement Anti-EGFR Antimétabolite Cancer Dérivé de la pyrimidine Dérivé de la quinazoline Enzyme Fluor Composé organique Homme Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Protein-tyrosine kinase Pyrimidine nucléoside Transferases Tumeur maligne
- Keyword (en)
- Antiangiogenic agent Antineoplastic agent Drug combination Lung cancer non-small cell lung carcinoma Chemotherapy Erlotinib Phase II trial Gemcitabine Patient Drug Elderly Randomization Sorafenib Advanced stage Treatment Antimetabolic Cancer Pyrimidine derivatives Quinazoline derivatives Enzyme Fluorine Organic compounds Human Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Respiratory disease Bronchus disease Lung disease Protein-tyrosine kinase Pyrimidine nucleoside Transferases Malignant tumor
- Keyword (es)
- Antiangiogenico Anticanceroso Asociación medicamentosa Cáncer del pulmón Carcinoma no pequeňa célula bronchopulmonar Quimioterapia Erlotinib Ensayo clínico fase II Gemcitabina Enfermo Medicamento Anciano Aleatorización Sorafenib Estadio avanzado Tratamiento Antimetabólito Cáncer Pirimidina derivado Enzima Fluor Compuesto orgánico Hombre Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Aparato respiratorio patología Bronquio patología Pulmón patología Protein-tyrosine kinase Pirimidina nucleósido Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11A Tumors of the respiratory system and mediastinum
- Discipline
- Pharmacological treatments Pulmonology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24317210
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/annonc/mdq630 
https://dx.doi.org/10.1093/annonc/mdq630
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