Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

Author

AGRAWAL, Nishant^{1 2} ; FREDERICK, Mitchell J³ ; NIANXIANG ZHANG⁶ ; EL-NAGGAR, Adel K⁷ ; JASSER, Samar A³ ; WEINSTEIN, John N⁶ ; TREVINO, Lisa⁵ ; DRUMMOND, Jennifer A⁵ ; MUZNY, Donna M⁵ ; YUANQING WU⁵ ; WOOD, Laura D⁸ ; HRUBAN, Ralph H⁸ ; PICKERING, Curtis R³ ; WESTRA, William H⁸ ; KOCH, Wayne M¹ ; CALIFANO, Joseph A^{1 9} ; GIBBS, Richard A^{10 5 9} ; SIDRANSKY, David¹ ; VOGELSTEIN, Bert² ; VELCULESCU, Victor E² ; PAPADOPOULOS, Nickolas² ; WHEELER, David A⁵ ; KINZLER, Kenneth W² ; BETTEGOWDA, Chetan^{2 4} ; MYERS, Jeffrey N³ ; CHANG, Kyle⁵ ; LI, Ryan J¹ ; FAKHRY, Carole¹ ; XIE, Tong-Xin³ ; JIEXIN ZHANG⁶ ; JING WANG⁶
[1] Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States
[2] Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, United States
[3] Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, United States
[4] Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States
[5] Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
[6] Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, United States
[7] Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, United States
[8] Department of Pathology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States
[9] Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21204, United States
[10] Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States

Source

Science (Washington, D.C.). 2011, Vol 333, Num 6046, pp 1154-1157, 4 p

CODEN

SCIEAS

ISSN

0036-8075

Scientific domain

Multidisciplinary

Publisher

American Association for the Advancement of Science, Washington, DC

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Cancer de la tête et du cou Cancérologie Carcinogenèse Carcinome épidermoïde de la tête et du cou Gène suppresseur tumeur Homme Inactivation Mutation Papillomavirus humain Tabagisme Virose Gène Notch1 Séquençage de l'exome Cancer Génétique Infection Papillomavirus Papovaviridae Pathologie ORL Tumeur maligne Virus

Keyword (en)

Head and neck cancer Cancerology Carcinogenesis Head and neck squamous cell carcinoma Tumor suppressor gene Human Inactivation Mutation Human papillomavirus Tobacco smoking Viral disease Exome sequencing Cancer Genetics Infection Papillomavirus Papovaviridae ENT disease Malignant tumor Virus

Keyword (es)

Cáncer de cabeza y cuello Cancerología Carcinogénesis Carcinoma epidermoideo cabeza cuello Gen supresor tumor Hombre Inactivación Mutación Human papillomavirus Tabaquismo Virosis Cáncer Genética Infección Papillomavirus Papovaviridae ORL patología Tumor maligno Virus

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B10 Otorhinolaryngology. Stomatology / 002B10A Otorhinolaryngology (head neck, general aspects and miscellaneous) / 002B10A01 Tumors

Discipline

Otorhinolaryngology. Stomatology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24473570

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS