Small molecule inhibitors reveal Niemann―Pick C1 is essential for Ebola virus infection
- Author
- COTE, Marceline1 ; MISASI, John1 2 ; CUNNINGHAM, James1 6 ; REN, Tao3 ; BRUCHEZ, Anna1 ; LEE, Kyungae3 ; MARIE FILONE, Claire1 4 ; HENSLEY, Lisa4 ; QI LI1 ; ORY, Daniel5 ; CHANDRAN, Kartik1
[1] Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States
[2] Division of Infectious Disease, Department of Medicine, Children's Hospital, Boston, Massachusetts 02115, United States
[3] New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, Harvard Medical School, Boston, Massachusetts 02115, United States
[4] United States Army Medical Research Institute of Infectious Diseases, Virology Division, Frederick, Maryland 21702, United States
[5] Diabetic Cardiovascular Disease Center, Washington University School of Medicine, Saint Louis, Missouri 63110, United States
[6] Department of Microbiology and Immunology, Harvard Medical School, Boston, Massachusetts 02115, United States - Source
Nature (London). 2011, Vol 477, Num 7364, pp 344-348, 5 p ; ref : 25 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiviral Clivage Cytokine Epidémiologie Evolution Fièvre hémorragique Ebola Glycoprotéine Homme Identification Immunoprophylaxie Lipide Mortalité Pathogénie Production Pronostic Protéine membranaire Prévention Traitement Transmission Vaccin Virus Ebola Protéine Niemann-Pick C1 Filoviridae Filovirus Infection Mononegavirales Virose Virus
- Keyword (en)
- Antiviral Cleavage Cytokine Epidemiology Evolution Ebola hemorrhagic fever Glycoprotein Human Identification Immunoprophylaxis Lipids Mortality Pathogenesis Production Prognosis Membrane protein Prevention Treatment Transmission Vaccine Ebola virus Filoviridae Filovirus Infection Mononegavirales Viral disease Virus
- Keyword (es)
- Antiviral Clivaje Citoquina Epidemiología Evolución Fiebre hemorrágica Ebola Glicoproteína Hombre Identificación Inmunoprofilaxia Lípido Mortalidad Patogenia Producción Pronóstico Proteína membranar Prevención Tratamiento Transmisión Vacuna Ebola virus Filoviridae Filovirus Infección Mononegavirales Virosis Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02I Tropical viral diseases / 002B05C02I4 Marburg disease, ebola disease
- Discipline
- Infectious pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24500748
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature10380 
https://dx.doi.org/10.1038/nature10380
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