Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function

Author

ARTIGAS, Maria Soler¹ ; WAIN, Louise V¹ ; KERR, Shona M⁸ ; SMITH, Blair H⁹ ; CADBY, Gemma^{10 11} ; HUI, Jennie^{12 13 14} ; PALMER, Lyle J^{10 11} ; HINGORANI, Aroon D¹⁵ ; WANNAMETHEE, S. Goya¹⁶ ; WHINCUP, Peter H¹⁷ ; EBRAHIM, Shah¹⁸ ; SMITH, George Davey¹⁹ ; REPAPI, Emmanouela^{1 2} ; BARROSO, Inês^{20 21} ; LOOS, Ruth J. F⁵ ; WAREHAM, Nicholas J⁵ ; COOPER, Cyrus²² ; DENNISON, Elaine²² ; SHAHEEN, Seif O²³ ; LIU, Jason Z²⁴ ; MARCHINI, Jonathan²⁴ ; DAHGAM, Santosh; NALUAI, Asa Torinsson; OBEIDAT, Ma'en³ ; OLIN, Anna-Carin; KARRASCH, Stefan; HEINRICH, Joachim; SCHULZ, Holger; MCKEEVER, Tricia M; PAVORD, Ian D; HELIÖVAARA, Markku; RIPATTI, Samuli; SURAKKA, Ida; BLAKEY, John D; SAYERS, Ian³ ; KÄHÖNEN, Mika; BRITTON, John R; NYBERG, Fredrik; HOLLOWAY, John W; LAWLOR, Debbie A; MORRIS, Richard W; JAMES, Alan L; JACKSON, Cathy M; HALL, Ian P³ ; TOBIN, Martin D¹ ; BURTON, Paul R¹ ; JOHNSON, Toby⁴ ; JING HUA ZHAO⁵ ; ALBRECHT, Eva⁶ ; DOMINICZAK, Anna F⁷
[1] Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom
[2] Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
[3] Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, United Kingdom
[4] Clinical Pharmacology, William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
[5] Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
[6] Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
[7] College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
[8] Medical Genetics, University of Edinburgh, Molecular Medicine Centre, Edinburgh, Scotland, United Kingdom
[9] Centre of Academic Primary Care, University of Aberdeen, Scotland, United Kingdom
[10] Ontario Institute for Cancer Research
[11] Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
[12] Molecular Genetics, PathWest Laboratory Medicine, Nedlands, Australia
[13] Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Nedlands, Australia
[14] Schools of Population Health and Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
[15] Department of Epidemiology and Public Health, University College London, London, United Kingdom
[16] Department of Primary Care and Population Health, University College London, London, United Kingdom
[17] Division of Community Health Sciences, St. George's University of London, London, United Kingdom
[18] Non-communicable Diseases Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
[19] MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
[20] Wellcome Trust Sanger Institute, Cambridge, United Kingdom
[21] University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
[22] MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
[23] Centre for Health Sciences, Barts and London School of Medicine, London, United Kingdom
[24] Department of Statistics, University of Oxford, Oxford, United Kingdom
Medical Research Council National Survey of Health and Dvelopment (NSHD) Respiratory Study Team

Source

American journal of respiratory and critical care medicine. 2011, Vol 184, Num 7, pp 786-795, 10 p ; ref : 35 ref

ISSN

1073-449X

Scientific domain

Pneumology

Publisher

American Thoracic Society, New York, NY

Publication country

United States

Document type

Article

Language

English

Author keyword

FEV₁ FVC genome-wide association study modeling risk

Keyword (fr)

Articulation Bronchopneumopathie chronique obstructive Facteur risque Fonction respiratoire Modélisation Réanimation Soin intensif Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Système ostéoarticulaire

Keyword (en)

Joint Chronic obstructive pulmonary disease Risk factor Lung function Modeling Resuscitation Intensive care Respiratory disease Bronchus disease Lung disease Osteoarticular system

Keyword (es)

Articulación Enfermedad pulmonar obstructiva crónica Factor riesgo Función respiratoria Modelización Reanimación Cuidado intensivo Aparato respiratorio patología Bronquio patología Pulmón patología Sistema osteoarticular

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11B Chronic obstructive pulmonary disease, asthma

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B27 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / 002B27B Intensive care medicine

Discipline

Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy Pulmonology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24598840

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS