A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
- Author
- STACEY, Simon N1 ; SULEM, Patrick1 ; RAGNARSSON, Rafn2 3 ; BENEDIKTSDOTTIR, Kristrun R2 3 ; NEXØ, Bjorn A4 ; TJONNELAND, Anne5 ; OVERVAD, Kim6 ; RUDNAI, Peter7 ; GURZAU, Eugene8 ; KOPPOVA, Kvetoslava9 ; HEMMINKI, Kari10 ; CORREDERA, Cristina11 ; JONASDOTTIR, Aslaug1 ; FUENTELSAZ, Victoria12 ; GRASA, Pilar11 ; NAVARRETE, Sebastian13 ; FUERTES, Fernando13 ; GARCIA-PRATS, Maria D14 ; SANAMBROSIO, Enrique15 ; PANADERO, Angeles16 ; DE JUAN, Ana17 ; GARCIA, Almudena17 ; RIVERA, Fernando17 ; MASSON, Gisli1 ; PLANELLES, Dolores18 ; SORIANO, Virtudes19 ; REQUENA, Celia20 ; ABEN, Katja K21 22 ; VAN ROSSUM, Michelle M23 ; CREMERS, Ruben G. H. M21 24 ; VAN OORT, Inge M24 ; VAN SPRONSEN, Dick-Johan; SCHALKEN, Jack A24 ; PETERS, Wilbert H. M; GUDMUNDSSON, Julius1 ; HELFAND, Brian T; DONOVAN, Jenny L; HAMDY, Freddie C; BADESCU, Daniel; CODREANU, Ovidiu; JINGA, Mariana; CSIKI, Irma E; CONSTANTINESCU, Vali; BADEA, Paula; MATES, Loan N; GUDBJARTSSON, Daniel F1 ; DINU, Daniela E; CONSTANTIN, Adrian; MATES, Dana; KRISTJANSDOTTIR, Sjofn; AGNARSSON, Bjarni A2 3 ; JONSSON, Eirikur2 3 ; BARKARDOTTIR, Rosa B2 3 ; EINARSSON, Gudmundur V2 ; SIGURDSSON, Fridbjorn2 ; MOLLER, Pall H2 ; MAGNUSSON, Olafur T1 ; GUDJONSSON, Sigurjon A1 ; SIGURGEIRSSON, Bardur2 3 ; THORISDOTTIR, Kristin2 3
[1] CODE genetics, Reykjavik, Iceland
[2] Landspitali-University Hospital, Reykjavik, Iceland
[3] Faculty of Medicine, University of Iceland, Reykjavik, Iceland
[4] Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
[5] Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
[6] Department of Epidemiology, School of Public Health, University of Aarhus, Aarhus, Denmark
[7] National Institute of Environmental Health, Budapest, Hungary
[8] Environmental Health Centre, Cluj, Cluj-Napoca, Romania
[9] State Health Institute, Banska Bystrica, Slovakia
[10] Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
[11] Division of Dermatology, University of Zaragoza, Zaragoza, Spain
[12] Division of Dermatology, Gregorio Marañon University Hospital, Madrid, Spain
[13] Division of Radiation Oncology, University of Zaragoza, Zaragoza, Spain
[14] Division of Pathology, San Jorge General Hospital, Huesca, Spain
[15] Division of Surgery, General Hospital, Soria, Spain
[16] Division of Medical Oncology, Ciudad de Coria Hospital, Coria, Spain
[17] Division of Medical Oncology, Marques de Valdecilla University Hospital, Santander, Spain
[18] Laboratory of Histocompatibility-Molecular Biology, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain
[19] Department of Oncology, Instituto Valenciano de Oncologia, Valencia, Spain
[20] Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
[21] Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
[22] Comprehensive Cancer Center The Netherlands, Location Nijmegen, Nijmegen, Netherlands
[23] Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
[24] Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands - Source
Nature genetics. 2011, Vol 43, Num 11, pp 1098-1103, 6 p ; ref : 23 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Gène TP53 Lignée germinale Tumeur maligne Variant Association génétique Signal de polyadénylation Cancer
- Keyword (en)
- TP53 Gene Germ line Malignant tumor Variant Polyadenylation signal Cancer
- Keyword (es)
- Gen TP53 Línea germinal Tumor maligno Variante Cáncer
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H04 Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24750148
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.926 
https://dx.doi.org/10.1038/ng.926
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