Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease
- Author
- WEBBER, S. E1 ; TIKHE, J1 ; BROWN, E. L1 ; DELISLE, D. M1 ; FORD, C. E1 ; BINFORD, S. L1 ; WORLAND, S. T1 ; FUHRMAN, S. A1 ; HENDRICKSON, T. F1 ; MATTHEWS, D. A1 ; LOVE, R. A1 ; PATICK, A. K1 ; MEADOR, J. W1 ; FERRE, R. A1
[1] Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, United States - Source
Journal of medicinal chemistry (Print). 1996, Vol 39, Num 26, pp 5072-5082 ; ref : 32 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiviral Carboxamide Composé aromatique Composé bicyclique Composé non peptide Homme Hétérocycle azote Hétérocycle soufre In vitro Indole dérivé Inhibiteur enzyme Isatine Modèle moléculaire Modélisation Méthode ab initio Picornain 3C Relation structure activité Rhinovirus 14 Synthèse chimique Indoline-2,3-dione(5-iodo) Indoline-5-carboxylique acide(1-[benzo[b]thién-2-yl]-2,3-dioxo) amide Indoline-5-carboxylique acide(1-[benzo[b]thién-2-yl]-2,3-dioxo-1-méthyl) amide Cysteine endopeptidases Enzyme Hydrolases Peptidases Picornaviridae Rhinovirus Virus
- Keyword (en)
- Antiviral Carboxamide Aromatic compound Bicyclic compound Non peptide compound Human Nitrogen heterocycle Sulfur heterocycle In vitro Indole derivatives Enzyme inhibitor Molecular model Modeling Ab initio method Picornain 3C Structure activity relation Rhinovirus 14 Chemical synthesis Cysteine endopeptidases Enzyme Hydrolases Peptidases Picornaviridae Rhinovirus Virus
- Keyword (es)
- Antiviral Carboxamida Compuesto aromático Compuesto bicíclico Compuesto no péptido Hombre Heterociclo nitrógeno Heterociclo azufre In vitro Indol derivado Inhibidor enzima Modelo molecular Modelización Método ab initio Picornain 3C Relación estructura actividad Rhinovirus 14 Síntesis química Cysteine endopeptidases Enzima Hydrolases Peptidases Picornaviridae Rhinovirus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2519653
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm960603e 
https://dx.doi.org/10.1021/jm960603e
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