Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- Author
- ANASTASIOU, Dimitrios1 2 ; POULOGIANNIS, George1 2 ; THOMAS, Craig J4 ; VANDER HEIDEN, Matthew G5 6 ; CANTLEY, Lewis C1 2 ; ASARA, John M1 3 ; BOXER, Matthew B4 ; JIANG, Jian-Kang4 ; MIN SHEN4 ; BELLINGER, Gary1 5 ; SASAKI, Atsuo T1 2 ; LOCASALE, Jason W1 2 ; AULD, Douglas S4
[1] Beth Israel Deaconess Medical Center, Department of Medidne-Division of Signal Transduction, Boston, MA 02115, United States
[2] Department of Systems Biology, Harvard Medical School, Boston, MA 02115, United States
[3] Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
[4] NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States
[5] Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, United States
[6] Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, United States - Source
Science (Washington, D.C.). 2011, Vol 334, Num 6060, pp 1278-1283, 6 p ; ref : 29 ref
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Cancer du poumon Cancérologie Espèces réactives de l'oxygène Homme Lignée cellulaire établie Pyruvate kinase Souris Stress oxydatif Tumorigénicité Lignée A549 Cancer Enzyme Mammalia Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Rodentia Transferases Tumeur maligne Vertebrata
- Keyword (en)
- Animal Lung cancer Cancerology Reactive oxygen species Human Established cell line Pyruvate kinase Mouse Oxidative stress Tumorigenicity Cancer Enzyme Mammalia Respiratory disease Bronchus disease Lung disease Rodentia Transferases Malignant tumor Vertebrata
- Keyword (es)
- Animal Cáncer del pulmón Cancerología Especies reactivas del oxígeno Hombre Línea celular establecida Pyruvate kinase Ratón Estrés oxidativo Tumorigenicidad Cáncer Enzima Mammalia Aparato respiratorio patología Bronquio patología Pulmón patología Rodentia Transferases Tumor maligno Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04D Animal tumors. Experimental tumors / 002B04D02 Experimental tumors, general aspects
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25274332
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1211485 
https://dx.doi.org/10.1126/science.1211485
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