Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
- Author
- SHEN, Ben-Quan1 ; KEYANG XU1 ; DONGWEI LI1 ; TIBBITTS, Jay1 ; BAUDYS, Jakub1 ; SAAD, Ola M1 ; SCALES, Suzie J1 ; MCDONALD, Paul J1 ; HASS, Philip E1 ; EIGENBROT, Charles1 ; NGUYEN, Trung1 ; SOLIS, Willy A1 ; LUNA LIU1 ; FUJI, Reina N; FLAGELLA, Kelly M; PATEL, Darshana; SPENCER, Susan D; KHAWLI, Leslie A; EBENS, Allen; LEE WONG, Wai; VANDLEN, Richard; KAUR, Surinder; SLIWKOWSKI, Mark X; RAAB, Helga1 ; SCHELLER, Richard H; POLAKIS, Paul; JUNUTULA, Jagath R; BHAKTA, Sunil1 ; KENRICK, Margaret1 ; PARSONS-REPONTE, Kathryn L1 ; TIEN, Janet1 ; YU, Shang-Fan1 ; MAIL, Elaine1
[1] Genentech Inc., 1 DNA Way, S, San Francisco, California, United States - Source
Nature biotechnology (Print). 2012, Vol 30, Num 2, pp 184-189, 6 p ; ref : 22 ref
- CODEN
- NABIF9
- ISSN
- 1087-0156
- Scientific domain
- Biotechnology
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Anticorps Composé conjugué Conjugaison Cystéine Immunomodulateur In vivo Médicament Stabilité Trastuzumab Anticorps monoclonal Thiol
- Keyword (en)
- Biological activity Antineoplastic agent Antibody Conjugated compound Conjugation Cysteine Immunomodulator In vivo Drug Stability Trastuzumab Monoclonal antibody Thiol
- Keyword (es)
- Actividad biológica Anticanceroso Anticuerpo Compuesto conjugado Conjugación Cisteína Inmunomodulador In vivo Medicamento Estabilidad Trastuzumab Anticuerpo monoclonal Tiol
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01G Miscellaneous
- Discipline
- Biotechnology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25522622
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nbt.2108 
https://dx.doi.org/10.1038/nbt.2108
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