The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine
- Author
- AZUMA, Junichi1 ; HASUNUMA, Tomoko2 ; KUBO, Masanori3 ; MIYATAKE, Masaya3 ; KOUE, Toshiko3 ; HIGASHI, Koushi3 ; FUJIWARA, Tsutomu3 ; KITAHARA, Sachiko3 ; KATANO, Tamiki3 ; HARA, Sumiko3
[1] Clinical Pharmacology and Pharmacogenomics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe 650-8530, Japan
[2] Research Center for Clinical Pharmacology, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-0072, Japan
[3] Department of Clinical Research and Development, Otsuka Pharmaceutical Co., Ltd, 3-2-27, Otedori, Chuo-ku, Osaka 540―021, Japan - Source
European journal of clinical pharmacology. 2012, Vol 68, Num 1, pp 29-37, 9 p ; ref : 25 ref
- ISSN
- 0031-6970
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Aripiprazole CYP2D6 polymorphism Drug interaction Fluvoxamine Paroxetine Pharmacokineties
- Keyword (fr)
- Antidépresseur Antipsychotique atypique Aripiprazole Cytochrome P450 Enzyme Fluvoxamine Génotype Homme Interaction médicamenteuse Isozyme Neuroleptique Paroxétine Pharmacocinétique Polymorphisme Psychotrope Variabilité génétique Cytochrome P4502D6 Agoniste partiel Antagoniste Dérivé de la pipéridine Inhibiteur recapture Inhibiteur sélectif recapture sérotonine Neurotransmetteur Quinolinone dérivé Récepteur dopaminergique D2 Récepteur sérotoninergique 5-HT1A Récepteur sérotoninergique 5-HT2A Sérotonine
- Keyword (en)
- Antidepressant agent Atypical antipsychotic Aripiprazole Cytochrome P450 Enzyme Fluvoxamine Genotype Human Drug interaction Isozyme Neuroleptic Paroxetine Pharmacokinetics Polymorphism Psychotropic Genetic variability Partial agonist Antagonist Piperidine derivatives Reuptake inhibitor Selective serotonin reuptake inhibitor Neurotransmitter Quinolinone derivatives D2 Dopamine receptor 5-HT1A Serotonine receptor 5-HT2A serotonin receptor Serotonin
- Keyword (es)
- Antidepresor Antipsicótico atípico Aripiprazol Citocromo P450 Enzima Fluvoxamina Genotipo Hombre Interacción medicamentosa Isozima Neuroléptico Paroxetina Farmacocinética Polimorfismo Psicotropo Variabilidad genética Agonista parcial Antagonista Piperidina derivado Inhibidor recaptura Inhibidor selectivo recaptura serotonin Neurotransmisor Quinolinona derivada Receptor dopaminérgico D2 Receptor serotoninérgico 5-HT1A Receptor serotoninérgico 5-HT2A Serotonina
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25566607
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00228-011-1094-4 
https://dx.doi.org/10.1007/s00228-011-1094-4
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