Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2
- Author
- CHENG ZHEN LIANG1 ; JIA KAI ZHANG1 ; ZHONGLI SHI2 ; BING LIU1 ; SHEN, Chengchun Q1 ; HUI MIN TAO1
[1] Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jie Fang Road, Hangzhou 310009, Zhejiang, China
[2] Institute of Orthopedic Research, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China - Source
Cancer chemotherapy and pharmacology. 2012, Vol 69, Num 2, pp 317-331, 15 p ; ref : 35 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Apoptosis Bcl-2 family Caspase Fas/FasL Matrine Osteosarcoma
- Keyword (fr)
- Antigène Fas Apoptose Caspase Cellule Cysteine endopeptidases Gène onc cellulaire Homme In vitro In vivo Ligand Fas Mort cellulaire Os Ostéosarcome Protooncogène Sarcome Gène bcl2 Cancer Enzyme Hydrolases Pathologie du système ostéoarticulaire Peptidases Système ostéoarticulaire Tumeur maligne
- Keyword (en)
- Fas Antigen Apoptosis Caspase Cell Cysteine endopeptidases C-Onc gene Human In vitro In vivo Fas ligand Cell death Bone Osteosarcoma Protooncogene Sarcoma Cancer Enzyme Hydrolases Diseases of the osteoarticular system Peptidases Osteoarticular system Malignant tumor
- Keyword (es)
- Antígeno Fas Apoptosis Caspase Célula Cysteine endopeptidases Gen onc celular Hombre In vitro In vivo Ligando Fas Muerte celular Hueso Osteosarcoma Protooncogen Sarcoma Cáncer Enzima Hydrolases Sistema osteoarticular patología Peptidases Sistema osteoarticular Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15C Tumors of striated muscle and skeleton
- Discipline
- Osteoarticular pathology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25577381
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-011-1699-4 
https://dx.doi.org/10.1007/s00280-011-1699-4
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