Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Author

ICHIMURA, Atsuhiko¹ ; HIRASAWA, Akira¹ ; CHOQUET, Helene^{2 3} ; BESNARD, Philippe⁴ ; LECOEUR, Cecile^{2 3} ; VIVEQUIN, Sidonie^{2 3} ; AYUKAWA, Kumiko¹ ; TAKEUCHI, Masato¹ ; OZAWA, Kentaro¹ ; TAUBER, Maithé⁵ ; MAFFEIS, Claudio^{6 7} ; MORANDI, Anita^{2 3 6} ; POULAIN-GODEFROY, Odile^{2 3} ; BUZZETTI, Raffaella⁸ ; ELLIOTT, Paul⁹ ; POUTA, Anneli^{10 11} ; JARVELIN, Marjo-Riitta^{10 12 9} ; KÖRNER, Antje¹³ ; KIESS, Wieland¹³ ; PIGEYRE, Marie^{14 15} ; CAIAZZO, Roberto^{14 16} ; HUL, Wim Van¹⁷ ; GAAL, Luc Van¹⁸ ; BONNEFOND, Amélie^{2 3} ; HORBER, Fritz¹⁹ ; BALKAU, Beverley^{20 21} ; LEVY-MARCHAL, Claire²² ; ROUSKAS, Konstantinos^{2 23 3} ; KOUVATSI, Anastasia²³ ; HEBEBRAND, Johannes²⁴ ; HINNEY, Anke²⁴ ; SCHERAG, Andre²⁵ ; PATTOU, François^{14 16} ; MEYRE, David^{2 3} ; HARA, Takafumi¹ ; KOSHIMIZU, Taka-Aki; WOLOWCZUK, Isabelle^{2 3} ; TSUJIMOTO, Gozoh¹ ; FROGUEL, Philippe^{2 3} ; YENGO, Loïc^{2 3} ; KIMURA, Ikuo¹ ; LELOIRE, Audrey^{2 3} ; NING LIU¹ ; IIDA, Keiko¹
[1] Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
[2] Centre National de la Recherche Scientifique(CNRS)-Unitemixtede recherche (UMR) 8199, Lille Pasteur I nstitute, Lille 59000, France
[3] Lille Nord de France University, Lille 59000, France
[4] Institut National de la Santé et de la Recherche Médicale (Inserm)-UMR U866, Physiologie de la Nutrition, Bourgogne University, AgroSup Dijon, Dijon 21078, France
[5] Inserm-U563, Children's Hospital, Centre Hospitalier Universitaire, Toulouse 31000, France
[6] Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona 37134, Italy
[7] Department of Mother and Child, Biology-Genetics, Section of Paediatrics, University of Verona, Verona 37134, Italy
[8] Department of Clinical Sciences, La Sapienza University, Rome 00161, Italy
[9] Medical Research Council-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's campus, Imperial College London, London W2 1PG, United Kingdom
[10] National Public Health Institute, Biocenter Oulu, University of Oulu, Oulu 90220, Finland
[11] Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu 90220, Finland
[12] Institute of Health Sciences, University of Oulu, Oulu 90220, Finland
[13] Center for Pediatric Research, Department of Women's & Child Health, University of Leipzig, Leipzig 04317, Germany
[14] Inserm-U859, Lille Nord de France University, Lille 59000, France
[15] Lille University Hospital, Nutrition, Lille 59000, France
[16] Lille University Hospital, Endocrine Surgery, Lille 59000, France
[17] Department of Medical Genetics, University of Antwerp, Antwerp 2610, Belgium
[18] Department of Endocrinology, Antwerp University Hospital, Antwerp 2650, Belgium
[19] Department of Surgery and Internal Medicine, Clinic Lindberg, Medical Department, Winterthur 8400, and University of Berne, Berne 3011, Switzerland
[20] Inserm-U780, Centre for research in Epidemiology and Population Health (CRESP), Villejuif 94800, France
[21] Paris-Sud 11 University, Orsay 91405, France
[22] Inserm-U690, Robert Debré hospital, Paris 75935, France
[23] Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece
[24] Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen 45147, Germany
[25] Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen 45122, Germany

Source

Nature (London). 2012, Vol 483, Num 7389, pp 350-354, 5 p ; ref : 26 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Acide gras insaturé Acide gras libre Aliment Alimentation Animal Appétit Etat nutritionnel Homme Homéostasie Lipide Matière grasse Nutriment Obésité Protéine G Récepteur biologique Souris Appareil digestif Hormone pancréatique Mammalia Rodentia Trouble de la nutrition Vertebrata

Keyword (en)

Unsaturated fatty acid Free fatty acid Food Feeding Animal Appetite Nutritional status Human Homeostasis Lipids Fat Nutrient Obesity G protein Biological receptor Mouse Digestive system Pancreatic hormone Mammalia Rodentia Nutrition disorder Vertebrata

Keyword (es)

Acido graso no saturado Acido graso libre Alimento Alimentación Animal Apetito Estado nutricional Hombre Homeostasis Lípido Materia grasa Nutriente Obesidad Proteína G Receptor biológico Ratón Aparato digestivo Hormona pancreática Mammalia Rodentia Trastorno nutricíon Vertebrata

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A25 Vertebrates: nervous system and sense organs

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22B Obesity

Discipline

Metabolic diseases Vertebrates : nervous system and sense organs

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

25600630

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS