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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Author
TURCAN, Sevin1 ; ROHLE, Daniel1 2 ; THOMPSON, Craig B4 ; KAUFMAN, Andrew1 ; GURYANOVA, Olga1 ; LEVINE, Ross1 ; HEGUY, Adriana1 ; VIALE, Agnes6 ; MORRIS, Luc G. T1 7 ; HUSE, Jason T1 8 ; MELLINGHOFF, Ingo K1 10 2 9 ; CHAN, Timothy A1 10 2 3 ; GOENKA, Anuj1 3 ; WALSH, Logan A1 ; FANG FANG1 ; YILMAZ, Emrullah1 ; CAMPOS, Carl1 ; FABIUS, Armida W. M1 ; CHAO LU4 5 ; WARD, Patrick S4 5
[1] Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[2] Weill Cornell College of Medicine, New York, New York 10065, United States
[3] Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[4] Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[5] Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, United States
[6] Genomics Core, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[7] Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[8] Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[9] Department of Neurology, Memorial Sloan-Kettering Cancer Center,, New York, New York 10065, United States
[10] Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
Source

Nature (London). 2012, Vol 483, Num 7390, pp 479-483, 5 p ; ref : 30 ref

CODEN
NATUAS
ISSN
0028-0836
Scientific domain
Multidisciplinary
Publisher
Nature Publishing Group, London
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Cancérologie Carcinogenèse Gliome malin Homme Isocitrate dehydrogenase (NADP+) Mutation Méthylation Phénotype Séquence nucléotide Séquence riche GC Hyperméthylation Cancer Enzyme Génétique Oxidoreductases Pathologie du système nerveux central Pathologie du système nerveux Tumeur maligne
Keyword (en)
Cancerology Carcinogenesis Malignant glioma Human Isocitrate dehydrogenase (NADP+) Mutation Methylation Phenotype Nucleotide sequence GC rich sequence Cancer Enzyme Genetics Oxidoreductases Central nervous system disease Nervous system diseases Malignant tumor
Keyword (es)
Cancerología Carcinogénesis Glioma maligno Hombre Isocitrate dehydrogenase (NADP+) Mutación Metilación Fenotipo Secuencia nucleótido Secuencia rica GC Cáncer Enzima Genética Oxidoreductases Sistema nervosio central patología Sistema nervioso patología Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses

Discipline
Neurology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
25618845

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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