An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
- Author
- OWEN, David R1 2 ; YEO, Astrid J3 ; STJEAN, Pamela L3 ; CARDON, Lon R3 ; MOOSER, Vincent E3 ; MATTHEWS, Paul M2 4 ; RABINER, Eugenii A2 4 ; RUBIO, Justin P3 ; GUNN, Roger N2 4 5 ; SONG, Kijoung3 ; WADSWORTH, Graham2 ; LEWIS, Andrew1 ; RHODES, Chris1 ; PULFORD, David J3 ; BENNACEF, Idriss2 ; PARKER, Christine A2 4
[1] Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
[2] Clinical Imaging Centre, GlaxoSmithKline Research and Development, Hammersmith Hospital, London, United Kingdom
[3] Genetics, GlaxoSmithKline Research and Development, Stevenage, UK and King of Prussia, PA and Research Triangle Park, North Carolina, United States
[4] Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
[5] Department of Engineering Science, University of Oxford, Oxford, United Kingdom - Source
Journal of cerebral blood flow and metabolism. 2012, Vol 32, Num 1, pp 1-5, 5 p ; ref : 3/4 p
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Ala147Thr PBR28 TSPO polymorphism radioligand binding
- Keyword (fr)
- Pathologie cérébrovasculaire Pathologie du système nerveux Polymorphisme Tomographie par émission de positons Tomoscintigraphie Pathologie de l'encéphale Pathologie du système nerveux central
- Keyword (en)
- Cerebrovascular disease Nervous system diseases Polymorphism Positron emission tomography Emission tomography Cerebral disorder Central nervous system disease
- Keyword (es)
- Vaso sanguíneo encéfalo patología Sistema nervioso patología Polimorfismo Tomografía emisión positrones Tomocentelleografía Encéfalo patología Sistema nervosio central patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17C Vascular diseases and vascular malformations of the nervous system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22E Other metabolic disorders / 002B22E04 Amyloidosis
- Discipline
- Metabolic diseases Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25665758
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/jcbfm.2011.147 
https://dx.doi.org/10.1038/jcbfm.2011.147
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