Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
- Author
- BOOTH, D. R1 ; SUNDE, M2 ; PEPYS, M. B1 ; BELLOTTI, V1 ; ROBINSON, C. V3 ; HUTCHINSON, W. L1 ; FRASER, P. E4 ; HAWKINS, P. N1 ; DOBSON, C. M3 ; RADFORD, S. E3 ; BLAKE, C. C. F2
[1] Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, United Kingdom
[2] Laboratory of Molecular Biophysics, Oxford Centre for Molecular Sciences, University of Oxford, Oxford OX1 3QT, United Kingdom
[3] New Chemistry Laboratory, Oxford Centre for Molecular Sciences, University of Oxford, Oxford OX1 3QT, United Kingdom
[4] Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto M5S 3H2, Canada - Source
Nature (London). 1997, Vol 385, Num 6619, pp 787-793 ; ref : 49 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Amyloïde Dynamique conformationnelle Fibrille Lysozyme Stabilité structurale Variant génétique Enzyme Glycoprotéine Glycosidases Hydrolases O-Glycosidases
- Keyword (en)
- Biological activity Amyloid Conformational dynamics Fibril Lysozyme Structure stability Genetic variant Enzyme Glycoproteins Glycosidases Hydrolases O-Glycosidases
- Keyword (es)
- Actividad biológica Amiloide Dinámica conformacional Fibrilla Lysozyme Estabilidad estructural Variante genética Enzima Glicoproteina Glycosidases Hydrolases O-Glycosidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Discipline
- Analytical, structural and metabolic biochemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2576034
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/385787a0 
https://dx.doi.org/10.1038/385787a0
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