Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
- Author
- ZHI JIANG ZANG1 2 ; CUTCUTACHE, Ioana3 ; HON LIM, Kiat7 ; KIAT ONG, Choon4 ; HUANG, Dachuan4 ; YUNG CHIN, Sze8 ; BEEHUAT TAN, Lain6 9 ; CHUAN YOUNG NG, Cedric4 ; WILLIE YU4 6 ; YINGTING WU10 ; LEE, Minghui1 ; WU, Jeanie1 ; POON, Song Ling4 ; POH, Dianne2 ; KEAT WAN, Wei7 ; YOUNG RHA, Sun11 ; SO, Jimmy12 ; SALTO-TELLEZ, Manuel13 8 ; GUAN YEOH, Khay14 ; WAI KEONG WONG15 ; ZHU, Yi-Jun16 ; FUTREAL, P. Andrew17 ; PANG, Brendan5 8 ; SHEN LI ZHANG2 ; YIJUN RUAN18 ; HILLMER, Axel M18 ; BERTRAND, Denis18 ; NAGARAJAN, Niranjan18 ; ROZEN, Steve3 ; TEAN TEH, Bin19 2 4 ; TAN, Patrick18 2 5 ; MCPHERSON, John R3 ; JIONG TAO2 5 ; RAJASEGARAN, Vikneswari4 ; HONG LEE HENG4 ; NIANTAO DENG2 6 ; GAN, Anna4
[1] Cellular and Molecular Research, National Cancer Centre, Singapore
[2] Cancer and Stem Cell Biology Program, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore
[3] Neuroscience and Behavioral Disorders, Duke―NUS Graduate Medical School, Singapore
[4] National Cancer Centre Singapore-Van Andel Research Institute Translational Research Laboratory, National Cancer Centre, Singapore
[5] Cancer Sciences Institute of Singapore, NUS, Singapore
[6] Graduate School for Integrative Sciences and Engineering, NUS, Singapore
[7] Department of Pathology, Singapore General Hospital, Singapore
[8] Department of Pathology, NUS, Singapore
[9] Division of Medical Oncology, National Cancer Centre, Singapore
[10] Computation and Systems Biology, Singapore-MIT Alliance, Singapore
[11] Department of Internal Medicine, Yonsei Cancer Centre, Yonsei University College of Medicine, Seoul, Korea, Republic of
[12] Department of Surgery, Yong Loo Lin School of Medicine (NUS), Singapore
[13] Centre for Cancer Research and Cell Biology, Queen's University, Belfast, United Kingdom
[14] Department of Medicine, Yong Loo Lin School of Medicine (NUS), Singapore
[15] Department of General Surgery, Singapore General Hospital, Singapore
[16] Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States
[17] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
[18] Genome Institute of Singapore, Singapore
[19] Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, United States - Source
Nature genetics. 2012, Vol 44, Num 5, pp 570-574, 5 p ; ref : 34 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Adhérence cellulaire Adénocarcinome de l'estomac Cancer de l'estomac Cellule somatique Gène Identification Mutation somatique Récidivant Séquençage Remodelage de la chromatine Cancer Pathologie de l'appareil digestif Pathologie de l'estomac Tumeur maligne
- Keyword (en)
- Cell adhesion Stomach adenocarcinoma Stomach cancer Somatic cell Gene Identification Somatic mutation Recurrent Sequencing Chromatin remodeling Cancer Digestive diseases Gastric disease Malignant tumor
- Keyword (es)
- Adherencia celular Adenocarcinoma de estómago Cáncer del estómago Célula somática Gen Identificación Mutación somática Recidivante Sequencing Cáncer Aparato digestivo patología Estómago patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Gastroenterology. Liver. Pancreas. Abdomen
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25876537
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.2246 
https://dx.doi.org/10.1038/ng.2246
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