Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
- Author
- BELL, Robert D1 2 ; WINKLER, Ethan A1 ; BERK, Bradford C2 ; ZLOKOVIC, Berislav V1 6 ; SINGH, Itender1 ; SAGARE, Abhay P1 ; DEANE, Rashid1 ; ZHENHUA WU1 ; HOLTZMAN, David M3 ; BETSHOLTZ, Christer4 ; ARMULIK, Annika4 5 ; SALLSTROM, Jan1
[1] Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, Rochester, New York 14642, United States
[2] Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, United States
[3] Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, Missouri 63110, United States
[4] Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden
[5] Institute of Neuropathology, University Hospital Zürich, 8091, Zürich, Switzerland
[6] Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, United States - Source
Nature (London). 2012, Vol 485, Num 7399, pp 512-516, 5 p ; ref : 30 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Apolipoprotéine E Barrière hématoencéphalique Démence d'Alzheimer Encéphale Forme moléculaire Pathogénie Peptidylprolyl isomerase Souris Vaisseau sanguin Appareil circulatoire Enzyme Isomerases Maladie dégénérative Mammalia Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Rodentia Vertebrata cis-trans-Isomerases
- Keyword (en)
- Animal Apolipoprotein E Blood brain barrier Alzheimer disease Encephalon Molecular form Pathogenesis Peptidylprolyl isomerase Mouse Blood vessel Circulatory system Enzyme Isomerases Degenerative disease Mammalia Cerebral disorder Central nervous system disease Nervous system diseases Rodentia Vertebrata cis-trans-Isomerases
- Keyword (es)
- Animal Apolipoproteína E Barrera hematoencefálica Demencia Alzheimer Encéfalo Forma molecular Patogenia Peptidylprolyl isomerase Ratón Vaso sanguíneo Aparato circulatorio Enzima Isomerases Enfermedad degenerativa Mammalia Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Rodentia Vertebrata cis-trans-Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C13 Organic mental disorders. Neuropsychology
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03M Organic mental disorders. Neuropsychology
- Discipline
- Neurology Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 25888176
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1038/nature11087 
https://dx.doi.org/10.1038/nature11087
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:9:\"\u0000*\u0000jtitle\";s:15:\"Nature (London)\";s:9:\"\u0000*\u0000stitle\";s:14:\"Nature (Lond.)\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:3:\"485\";s:8:\"\u0000*\u0000issue\";s:4:\"7399\";s:8:\"\u0000*\u0000spage\";s:3:\"512\";s:8:\"\u0000*\u0000epage\";s:3:\"516\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-0836\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"BELL\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Robert D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:16:\"WINKLER, Ethan A\";i:1;s:16:\"BERK, Bradford C\";i:2;s:20:\"ZLOKOVIC, Berislav V\";i:3;s:14:\"SINGH, Itender\";i:4;s:15:\"SAGARE, Abhay P\";i:5;s:13:\"DEANE, Rashid\";i:6;s:10:\"ZHENHUA WU\";i:7;s:17:\"HOLTZMAN, David M\";i:8;s:19:\"BETSHOLTZ, Christer\";i:9;s:15:\"ARMULIK, Annika\";i:10;s:14:\"SALLSTROM, Jan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NATUAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"5\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:9:\"\u0000*\u0000jtitle\";s:15:\"Nature (London)\";s:9:\"\u0000*\u0000stitle\";s:14:\"Nature (Lond.)\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:3:\"485\";s:8:\"\u0000*\u0000issue\";s:4:\"7399\";s:8:\"\u0000*\u0000spage\";s:3:\"512\";s:8:\"\u0000*\u0000epage\";s:3:\"516\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-0836\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"BELL\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Robert D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:16:\"WINKLER, Ethan A\";i:1;s:16:\"BERK, Bradford C\";i:2;s:20:\"ZLOKOVIC, Berislav V\";i:3;s:14:\"SINGH, Itender\";i:4;s:15:\"SAGARE, Abhay P\";i:5;s:13:\"DEANE, Rashid\";i:6;s:10:\"ZHENHUA WU\";i:7;s:17:\"HOLTZMAN, David M\";i:8;s:19:\"BETSHOLTZ, Christer\";i:9;s:15:\"ARMULIK, Annika\";i:10;s:14:\"SALLSTROM, Jan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NATUAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"5\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:9:\"\u0000*\u0000jtitle\";s:15:\"Nature (London)\";s:9:\"\u0000*\u0000stitle\";s:14:\"Nature (Lond.)\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:3:\"485\";s:8:\"\u0000*\u0000issue\";s:4:\"7399\";s:8:\"\u0000*\u0000spage\";s:3:\"512\";s:8:\"\u0000*\u0000epage\";s:3:\"516\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-0836\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"BELL\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Robert D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:16:\"WINKLER, Ethan A\";i:1;s:16:\"BERK, Bradford C\";i:2;s:20:\"ZLOKOVIC, Berislav V\";i:3;s:14:\"SINGH, Itender\";i:4;s:15:\"SAGARE, Abhay P\";i:5;s:13:\"DEANE, Rashid\";i:6;s:10:\"ZHENHUA WU\";i:7;s:17:\"HOLTZMAN, David M\";i:8;s:19:\"BETSHOLTZ, Christer\";i:9;s:15:\"ARMULIK, Annika\";i:10;s:14:\"SALLSTROM, Jan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NATUAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"5\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:9:\"\u0000*\u0000jtitle\";s:15:\"Nature (London)\";s:9:\"\u0000*\u0000stitle\";s:14:\"Nature (Lond.)\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:3:\"485\";s:8:\"\u0000*\u0000issue\";s:4:\"7399\";s:8:\"\u0000*\u0000spage\";s:3:\"512\";s:8:\"\u0000*\u0000epage\";s:3:\"516\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-0836\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"BELL\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Robert D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:16:\"WINKLER, Ethan A\";i:1;s:16:\"BERK, Bradford C\";i:2;s:20:\"ZLOKOVIC, Berislav V\";i:3;s:14:\"SINGH, Itender\";i:4;s:15:\"SAGARE, Abhay P\";i:5;s:13:\"DEANE, Rashid\";i:6;s:10:\"ZHENHUA WU\";i:7;s:17:\"HOLTZMAN, David M\";i:8;s:19:\"BETSHOLTZ, Christer\";i:9;s:15:\"ARMULIK, Annika\";i:10;s:14:\"SALLSTROM, Jan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NATUAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"5\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:19:\"10.1038\/nature11087\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:9:\"\u0000*\u0000jtitle\";s:15:\"Nature (London)\";s:9:\"\u0000*\u0000stitle\";s:14:\"Nature (Lond.)\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:3:\"485\";s:8:\"\u0000*\u0000issue\";s:4:\"7399\";s:8:\"\u0000*\u0000spage\";s:3:\"512\";s:8:\"\u0000*\u0000epage\";s:3:\"516\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0028-0836\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:4:\"BELL\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Robert D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:16:\"WINKLER, Ethan A\";i:1;s:16:\"BERK, Bradford C\";i:2;s:20:\"ZLOKOVIC, Berislav V\";i:3;s:14:\"SINGH, Itender\";i:4;s:15:\"SAGARE, Abhay P\";i:5;s:13:\"DEANE, Rashid\";i:6;s:10:\"ZHENHUA WU\";i:7;s:17:\"HOLTZMAN, David M\";i:8;s:19:\"BETSHOLTZ, Christer\";i:9;s:15:\"ARMULIK, Annika\";i:10;s:14:\"SALLSTROM, Jan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"NATUAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:69:\"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"5\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
