Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects
- Author
- BORTOLOZZI, A1 2 3 ; CASTANE, A1 3 ; PERALES, J. C4 ; MONTEFELTRO, A5 ; ARTIGAS, F1 3 ; SEMAKOVA, J4 ; SANTANA, N1 3 ; ALVARADO, G5 ; CORTES, R1 6 ; FERRES-COY, A1 2 ; FERNANDEZ, G5 ; CARMONA, M. C5 ; TOTH, M7
[1] Department of Neurochemistry and Neuropharmacology, IIBB - CSIC - IDIBAPS, Barcelona, Spain
[2] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
[3] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
[4] Department of Physiological Sciences II, School of Medicine, Bellvitge, University of Barcelona, Barcelona, Spain
[5] Therapeutics, S.L., La Coruña, Spain
[6] Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
[7] Department of Pharmacology, Weill Medical College, Cornell University, New York, NY, United States - Source
Molecular psychiatry. 2012, Vol 17, Num 6, pp 612-623, 12 p ; ref : 45 ref
- ISSN
- 1359-4184
- Scientific domain
- Biochemistry, molecular biology, biophysics; Cognition; Psychology, psychopathology, psychiatry
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 5-HT1A receptors anti-depressant drug design anxiety major depression serotonin neurons small-interfering RNA
- Keyword (fr)
- Angoisse anxiété Antidépresseur Autorécepteur Etat dépressif Neurone sérotoninergique Psychotrope Récepteur sérotoninergique 5-HT1A Affect affectivité Trouble de l'humeur
- Keyword (en)
- Anxiety Antidepressant agent Autoreceptor Depression Serotoninergic neuron Psychotropic 5-HT1A Serotonine receptor Affect affectivity Mood disorder
- Keyword (es)
- Angustia ansiedad Antidepresor Autoreceptor Estado depresivo Neurona serotoninérgica Psicotropo Receptor serotoninérgico 5-HT1A Afecto afectividad Trastorno humor
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C07 Mood disorders / 002B18C07A Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03G Mood disorders / 770-D03G01 Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 25952947
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1038/mp.2011.92 
https://dx.doi.org/10.1038/mp.2011.92
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:9:\"\u0000*\u0000jtitle\";s:20:\"Molecular psychiatry\";s:9:\"\u0000*\u0000stitle\";s:15:\"Mol. psychiatry\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"6\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"623\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1359-4184\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:10:\"BORTOLOZZI\";s:10:\"\u0000*\u0000aufirst\";s:1:\"A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:10:\"CASTANE, A\";i:1;s:13:\"PERALES, J. C\";i:2;s:14:\"MONTEFELTRO, A\";i:3;s:10:\"ARTIGAS, F\";i:4;s:11:\"SEMAKOVA, J\";i:5;s:10:\"SANTANA, N\";i:6;s:11:\"ALVARADO, G\";i:7;s:9:\"CORTES, R\";i:8;s:13:\"FERRES-COY, A\";i:9;s:12:\"FERNANDEZ, G\";i:10;s:13:\"CARMONA, M. C\";i:11;s:7:\"TOTH, M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:9:\"\u0000*\u0000jtitle\";s:20:\"Molecular psychiatry\";s:9:\"\u0000*\u0000stitle\";s:15:\"Mol. psychiatry\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"6\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"623\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1359-4184\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:10:\"BORTOLOZZI\";s:10:\"\u0000*\u0000aufirst\";s:1:\"A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:10:\"CASTANE, A\";i:1;s:13:\"PERALES, J. C\";i:2;s:14:\"MONTEFELTRO, A\";i:3;s:10:\"ARTIGAS, F\";i:4;s:11:\"SEMAKOVA, J\";i:5;s:10:\"SANTANA, N\";i:6;s:11:\"ALVARADO, G\";i:7;s:9:\"CORTES, R\";i:8;s:13:\"FERRES-COY, A\";i:9;s:12:\"FERNANDEZ, G\";i:10;s:13:\"CARMONA, M. C\";i:11;s:7:\"TOTH, M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:9:\"\u0000*\u0000jtitle\";s:20:\"Molecular psychiatry\";s:9:\"\u0000*\u0000stitle\";s:15:\"Mol. psychiatry\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"6\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"623\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1359-4184\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:10:\"BORTOLOZZI\";s:10:\"\u0000*\u0000aufirst\";s:1:\"A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:10:\"CASTANE, A\";i:1;s:13:\"PERALES, J. C\";i:2;s:14:\"MONTEFELTRO, A\";i:3;s:10:\"ARTIGAS, F\";i:4;s:11:\"SEMAKOVA, J\";i:5;s:10:\"SANTANA, N\";i:6;s:11:\"ALVARADO, G\";i:7;s:9:\"CORTES, R\";i:8;s:13:\"FERRES-COY, A\";i:9;s:12:\"FERNANDEZ, G\";i:10;s:13:\"CARMONA, M. C\";i:11;s:7:\"TOTH, M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:9:\"\u0000*\u0000jtitle\";s:20:\"Molecular psychiatry\";s:9:\"\u0000*\u0000stitle\";s:15:\"Mol. psychiatry\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"6\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"623\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1359-4184\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:10:\"BORTOLOZZI\";s:10:\"\u0000*\u0000aufirst\";s:1:\"A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:10:\"CASTANE, A\";i:1;s:13:\"PERALES, J. C\";i:2;s:14:\"MONTEFELTRO, A\";i:3;s:10:\"ARTIGAS, F\";i:4;s:11:\"SEMAKOVA, J\";i:5;s:10:\"SANTANA, N\";i:6;s:11:\"ALVARADO, G\";i:7;s:9:\"CORTES, R\";i:8;s:13:\"FERRES-COY, A\";i:9;s:12:\"FERNANDEZ, G\";i:10;s:13:\"CARMONA, M. C\";i:11;s:7:\"TOTH, M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:18:\"10.1038\/mp.2011.92\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:9:\"\u0000*\u0000jtitle\";s:20:\"Molecular psychiatry\";s:9:\"\u0000*\u0000stitle\";s:15:\"Mol. psychiatry\";s:7:\"\u0000*\u0000date\";s:4:\"2012\";s:9:\"\u0000*\u0000volume\";s:2:\"17\";s:8:\"\u0000*\u0000issue\";s:1:\"6\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"623\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"1359-4184\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:10:\"BORTOLOZZI\";s:10:\"\u0000*\u0000aufirst\";s:1:\"A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:10:\"CASTANE, A\";i:1;s:13:\"PERALES, J. C\";i:2;s:14:\"MONTEFELTRO, A\";i:3;s:10:\"ARTIGAS, F\";i:4;s:11:\"SEMAKOVA, J\";i:5;s:10:\"SANTANA, N\";i:6;s:11:\"ALVARADO, G\";i:7;s:9:\"CORTES, R\";i:8;s:13:\"FERRES-COY, A\";i:9;s:12:\"FERNANDEZ, G\";i:10;s:13:\"CARMONA, M. C\";i:11;s:7:\"TOTH, M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:103:\"Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects\";s:8:\"\u0000*\u0000place\";s:11:\"Basingstoke\";s:6:\"\u0000*\u0000pub\";s:23:\"Nature Publishing Group\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
