The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Author

CURTIS, Christina^{1 2} ; SHAH, Sohrab P^{3 4} ; GRÄF, Stefan^{1 2} ; HA, Gavin³ ; HAFFARI, Gholamreza³ ; BASHASHATI, Ali³ ; RUSSELL, Roslin² ; MCKINNEY, Steven^{3 4} ; LANGERØD, Anita⁶ ; GREEN, Andrew⁷ ; PROVENZANO, Elena⁸ ; WISHART, Gordon⁸ ; CHIN, Suet-Feung^{1 2} ; PINDER, Sarah⁹ ; WATSON, Peter^{10 3 4} ; MARKOWETZ, Florian^{1 2} ; MURPHY, Leigh¹⁰ ; ELLIS, Ian⁷ ; PURUSHOTHAM, Arnie^{11 9} ; BØRRESEN-DALE, Anne-Lise^{12 6} ; BRENTON, James D^{13 2} ; TAVARE, Simon^{1 14 2 5} ; CALDAS, Carlos^{1 13 2 8} ; TURASHVILI, Gulisa^{3 4} ; APARICIO, Samuel^{3 4} ; RUEDA, Oscar M^{1 2} ; DUNNING, Mark J² ; SPEED, Doug^{2 5} ; LYNCH, Andy G^{1 2} ; SAMARAJIWA, Shamith^{1 2} ; YINYIN YUAN^{1 2}
[1] Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
[2] Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, United Kingdom
[3] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
[4] Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1 L3, Canada
[5] Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 OWA, United Kingdom
[6] Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
[7] Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, United Kingdom
[8] Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, United Kingdom
[9] King's College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, United Kingdom
[10] Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
[11] NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London WC2R 2LS, United Kingdom
[12] Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
[13] Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 ORE, United Kingdom
[14] Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, United States

Source

Nature (London). 2012, Vol 486, Num 7403, pp 346-352, 7 p ; ref : 29 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Cancer du sein Expression génique Homme Nombre copie Sein Cancer Pathologie de la glande mammaire Pathologie du sein Tumeur maligne

Keyword (en)

Breast cancer Gene expression Human Copy number Breast Cancer Mammary gland diseases Breast disease Malignant tumor

Keyword (es)

Cáncer del pecho Expresión genética Hombre Número copia Seno Cáncer Glándula mamaria patología Seno patología Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution / 002A07C Classical genetics, quantitative genetics, hybrids / 002A07C03 Human

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors

Discipline

Eukaryotes genetics. Biological and molecular evolution Gynecology. Andrology. Obstetrics

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

26003171

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS