The clonal and mutational evolution spectrum of primary triple―negative breast cancers

Author

SHAH, Sohrab P^{1 2} ; ROTH, Andrew^{1 2} ; BASHASHATI, Ali^{1 2} ; PRENTICE, Leah M^{1 2} ; KHATTRA, Jaswinder^{1 2} ; BURLEIGH, Angela^{1 2} ; YAP, Damian^{1 2} ; BERNARD, Virginie⁴ ; MCPHERSON, Andrew^{1 2} ; SHUMANSKY, Karey^{1 2} ; CRISAN, Anamaria^{1 2} ; GIULIANY, Ryan^{1 2} ; GOYA, Rodrigo³ ; HERAVI-MOUSSAVI, Alireza² ; ROSNER, Jamie² ; LAI, Daniel² ; BIROL, Inane³ ; VARHOL, Richard³ ; TAM, Angela³ ; DHALLA, Noreen³ ; ZENG, Thomas³ ; MA, Kevin³ ; CHAN, Simon K³ ; OLOUMI, Arusha^{1 2} ; GRIFFITH, Malachi³ ; MORADIAN, Annie³ ; GRACE CHENG, S.-W³ ; MORIN, Gregg B^{3 5} ; WATSON, Peter⁶ ; GELMON, Karen⁶ ; CHIA, Stephen⁶ ; CHIN, Suet-Feung^{7 8} ; CURTIS, Christina^{7 8 9} ; RUEDA, Oscar M^{7 8} ; HA, Gavin^{1 2} ; PHAROAH, Paul D⁷ ; DAMARAJU, Sambasivarao¹⁰ ; MACKEY, John¹⁰ ; HOON, Kelly¹¹ ; HARKINS, Timothy¹¹ ; TADIGOTLA, Vasisht¹¹ ; SIGAROUDINIA, Mahvash¹² ; GASCARD, Philippe¹² ; TLSTY, Thea¹² ; COSTELLO, Joseph F¹³ ; YONGJUN ZHAO³ ; MEYER, Irmtraud M^{14 5} ; EAVES, Connie J¹⁶ ; WASSERMAN, Wyeth W^{4 5} ; JONES, Steven^{17 3 5} ; HUNTSMAN, David^{18 2} ; HIRST, Martin^{15 19 3} ; CALDAS, Carlos^{20 21 7 8} ; MARRA, Marco A^{3 5} ; APARICIO, Samuel; TURASHVILI, Gulisa^{1 2} ; JIARUI DING^{1 2} ; TSE, Kane³ ; HAFFARI, Gholamreza^{1 2}
[1] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
[2] Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
[3] Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1 L3, Canada
[4] Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
[5] Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
[6] British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
[7] Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, United Kingdom
[8] Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
[9] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States
[10] Departments of Oncology and Laboratory Medicine and Pathology, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
[11] Life Technologies, 101 Lincoln Centre Dr., Foster City, California 94404, United States
[12] Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, United States
[13] Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, United States
[14] Department of Computer Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
[15] Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
[16] Terry Fox Laboratory, BC Cancer Agency, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
[17] Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A1S6, Canada
[18] Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Ave, Vancouver, British Columbia V5Z 4E6, Canada
[19] Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
[20] Cambridge Breast Unit, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, United Kingdom
[21] Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 ORE, United Kingdom

Source

Nature (London). 2012, Vol 486, Num 7403, pp 395-399, 5 p ; ref : 23 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing Group, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

1-Phosphatidylinositol 3-kinase Cancérologie Carcinogenèse Clonalité Gène PTEN Gène TP53 Gène suppresseur tumeur Mutation somatique Cancer du sein triple négatif Cancer Enzyme Génétique Pathologie de la glande mammaire Pathologie du sein Transferases Tumeur maligne

Keyword (en)

1-Phosphatidylinositol 3-kinase Cancerology Carcinogenesis Clonality PTEN Gene TP53 Gene Tumor suppressor gene Somatic mutation Triple negative breast cancer Cancer Enzyme Genetics Mammary gland diseases Breast disease Transferases Malignant tumor

Keyword (es)

1-Phosphatidylinositol 3-kinase Cancerología Carcinogénesis Clonalidad Gen PTEN Gen TP53 Gen supresor tumor Mutación somática Cáncer de pecho triple negativo Cáncer Enzima Genética Glándula mamaria patología Seno patología Transferases Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors

Discipline

Gynecology. Andrology. Obstetrics

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

26003180

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS