Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
- Author
- MISALE, Sandra1 2 ; YAEGER, Rona3 ; BENCARDINO, Katia7 ; CERCEK, Andrea3 ; CHEN, Chin-Tung5 ; VERONESE, Silvio6 ; ZANON, Carlo1 ; SARTORE-BIANCHI, Andrea7 ; GAMBACORTA, Marcello6 ; GALLICCHIO, Margherita8 ; VAKIANI, Efsevia9 ; BOSCARO, Valentina8 ; HOBOR, Sebastijan1 ; MEDICO, Enzo10 2 ; WEISER, Martin5 ; SIENA, Salvatore7 ; DI NICOLANTONIO, Federica1 11 ; SOLIT, David3 4 ; BARDELLI, Alberto1 11 2 ; SCALA, Elisa1 2 ; JANAKIRAMAN, Manickam4 ; LISKA, David5 ; VALTORTA, Emanuele6 ; SCHIAVO, Roberta7 ; BUSCARINO, Michela1 2 ; SIRAVEGNA, Giulia1
[1] Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
[2] Department of Oncological Sciences, University of Torino Medical School, 10060 Candiolo (Torino), Italy
[3] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[4] Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[5] Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[6] Division of Pathology, Ospedale Niguarda Ca' Granda, 20162 Milano, Italy
[7] Falck Division of Medical Oncology, Ospedale Niguarda Ca' Granda, 20162 Milano, Italy
[8] Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, 10125 Torino, Italy
[9] Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States
[10] Laboratory of Functional Genomics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
[11] FIRC Institute of Molecular Oncology (IFOM), 20139 Milano, Italy - Source
Nature (London). 2012, Vol 486, Num 7404, pp 532-536, 5 p ; ref : 19 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cancer colorectal Cancérologie Cétuximab Gène K ras Gène onc cellulaire Homme Immunothérapie Mutation Protooncogène Résistance traitement Traitement Anticorps monoclonal Cancer Génétique Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum Récepteur facteur croissance épiderme Tumeur maligne
- Keyword (en)
- Antineoplastic agent Colorectal cancer Cancerology Cetuximab K ras Gene C-Onc gene Human Immunotherapy Mutation Protooncogene Treatment resistance Treatment Monoclonal antibody Cancer Genetics Digestive diseases Intestinal disease Colonic disease Rectal disease Epidermal growth factor receptor Malignant tumor
- Keyword (es)
- Anticanceroso Cancer de colon y recto Cancerología Cetuximab Gen K ras Gen onc celular Hombre Inmunoterapia Mutación Protooncogen Resistencia tratamiento Tratamiento Anticuerpo monoclonal Cáncer Genética Aparato digestivo patología Intestino patología Colón patología Recto patología Receptor del factor de crecimiento epidérmico Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R03 Immunotherapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26036574
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature11156 
https://dx.doi.org/10.1038/nature11156
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