Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients
- Author
- CHU, Xiao-Man1 ; ZHANG, Li-Fang2 ; WANG, Guang-Ji2 ; ZHANG, Shen-Ning3 ; ZHOU, Jia-Hui1 ; HAO, Hai-Ping2
[1] Department of Clinical Pharmacology, Jinling Hospital, Nanjing, China
[2] State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, No. 24, Tongjiaxiang Street, Nanjing 210009, China
[3] Department of Neurology, Jinling Hospital, Nanjing, China - Source
European journal of clinical pharmacology. 2012, Vol 68, Num 10, pp 1395-1401, 7 p ; ref : 38 ref
- ISSN
- 0031-6970
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Drug combination Pharmacokinetics Polymorphisms UDP-glucuronosyltransferase Valproic acid
- Keyword (fr)
- Acide valproïque Association médicamenteuse Chinois Epilepsie Génotype Homme Normothymique Pharmacocinétique Polymorphisme UDP-glucuronosyltransferase Variabilité génétique Chine 4-Aminobutyrate transaminase Anticonvulsivant Enzyme Glycosyltransferases Hexosyltransferases Inhibiteur enzyme Inhibiteur histone deacetylase Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Transaminases Transferases Asie
- Keyword (en)
- Valproic acid Drug combination Chinese Epilepsy Genotype Human Mood stabilizer Pharmacokinetics Polymorphism UDP-glucuronosyltransferase Genetic variability China 4-Aminobutyrate transaminase Anticonvulsant Enzyme Glycosyltransferases Hexosyltransferases Enzyme inhibitor Histone deacetylase inhibitor Cerebral disorder Central nervous system disease Nervous system diseases Transaminases Transferases Asia
- Keyword (es)
- Acido valproico Asociación medicamentosa Chino Epilepsia Genotipo Hombre Estabilizador humor Farmacocinética Polimorfismo UDP-glucuronosyltransferase Variabilidad genética China 4-Aminobutyrate transaminase Anticonvulsivante Enzima Glycosyltransferases Hexosyltransferases Inhibidor enzima Inhibidor histone deacetylase Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Transaminases Transferases Asia
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17A Nervous system (semeiology, syndromes) / 002B17A03 Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
- Discipline
- General pharmacology Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26336529
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00228-012-1277-7 
https://dx.doi.org/10.1007/s00228-012-1277-7
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