RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-induced bone destruction in an estrogen receptor-positive breast cancer bone metastasis model
- Author
- CANON, Jude1 ; BRYANT, Rebecca1 ; ROUDIER, Martine2 ; BRANSTETTER, Daniel G2 ; DOUGALL, William C3
[1] Department of Oncology Research, Amgen Inc, 1 Amgen Center Drive, Thousand Oaks, CA 91320, United States
[2] Department of Pathology, Amgen Inc, Seattle, WA, United States
[3] Department of Oncology Research, Amgen Inc, Seattle, WA, United States - Source
Breast cancer research and treatment. 2012, Vol 135, Num 3, pp 771-780, 10 p ; ref : 25 ref
- CODEN
- BCTRD6
- ISSN
- 0167-6806
- Scientific domain
- Medical oncology; Obstetrics, gynecology, andrology; Pharmacology drugs
- Publisher
- Springer, Dordrecht
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Bone metastases Breast cancer Estrogen-receptor positive Osteoprotegerin RANKL Tamoxifen
- Keyword (fr)
- Anticancéreux Cancer du sein Efficacité traitement Facteur nécrose tumorale Inhibiteur Inhibition Ligand RANKL Modèle Métastase mammaire Métastase osseuse Prévention Récepteur hormonal Récepteur oestrogène Tamoxifène Traitement associé Cancer de l'os Ostéoprotégérine Tumeur osseuse Antihormone Antioestrogène Cancer Composé non stéroïde Cytokine Modulateur sélectif des récepteurs aux oestrogènes Pathologie de la glande mammaire Pathologie du sein Pathologie du système ostéoarticulaire Tumeur maligne
- Keyword (en)
- Antineoplastic agent Breast cancer Treatment efficiency Tumor necrosis factor Inhibitor Inhibition Receptor activator Nfkb ligand Models Breast metastasis Bone metastasis Prevention Hormonal receptor Estrogen receptor Tamoxifene Combined treatment Bone cancer Osteoprotegerin Bone tumor Antihormone Antiestrogen Cancer Non steroid compound Cytokine Selective estrogen receptor modulator Mammary gland diseases Breast disease Diseases of the osteoarticular system Malignant tumor
- Keyword (es)
- Anticanceroso Cáncer del pecho Eficacia tratamiento Factor necrosis tumoral Inhibidor Inhibición Ligando RANKL Modelo Metástasis mamaria Metástasis ósea Prevención Receptor hormonal Receptor estrógeno Tamoxifeno Tratamiento asociado Antihormona Antiestrógeno Cáncer Compuesto no esteroide Citoquina Modulador selectivo del receptor de estrógeno Glándula mamaria patología Seno patología Sistema osteoarticular patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15C Tumors of striated muscle and skeleton
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors
- Discipline
- Gynecology. Andrology. Obstetrics Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26346082
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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